Bulletin of the Korean Chemical Society

  • 제29권9호
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  • Pages.1752-1754
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  • 2008
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using HClO4-SiO2 as a Heterogeneous and Recyclable Catalyst

  • Maheswara, Muchchintala (Department of Advanced Materials for Information and Display, Pusan National University) ;
  • Oh, Sang-Hyun (Department of Advanced Materials for Information and Display, Pusan National University) ;
  • Kim, Ke-Tack (Korea Electrotechnology Research Institute) ;
  • Do, Jung-Yun (Department of Advanced Materials for Information and Display, Pusan National University)
  • 발행 : 2008.09.30
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초록

A simple and efficient synthesis of 3,4-dihydropyrimidinones or thiones is described, using silica-supported perchloric acid ($HClO_4-SiO_2$) as a heterogeneous catalyst from an aldehyde, $\beta$-dicarbonyl compound, and urea or thiourea under solvent-free conditions. Compared to the classical Biginelli reactions, this method consistently has the advantage of high yields, short reaction time, easy separation, and tolerance towards various functional groups.

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참고문헌

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  5. as a Heterogeneous and Recyclable Catalyst. vol.40, pp.5, 2009, https://doi.org/10.1002/chin.200905164
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  10. Solvent-free synthesis of 6-unsubstituted dihydropyrimidinones using 2-pyrrolidonium bisulphate as efficient catalyst vol.70, pp.8, 2016, https://doi.org/10.1515/chempap-2016-0048
  11. Biginelli Reaction: Polymer Supported Catalytic Approaches vol.21, pp.3, 2019, https://doi.org/10.1021/acscombsci.8b00120
  12. HClO 4 ‐Al 2 O 3 as a Prominent Catalyst in the Synthesis of 3,4‐Dihydropyrimidin‐2(1 H )‐ones/thiones under Environmentally Friendly Solve vol.5, pp.28, 2008, https://doi.org/10.1002/slct.202001830