Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using HClO4-SiO2 as a Heterogeneous and Recyclable Catalyst

  • Maheswara, Muchchintala (Department of Advanced Materials for Information and Display, Pusan National University) ;
  • Oh, Sang-Hyun (Department of Advanced Materials for Information and Display, Pusan National University) ;
  • Kim, Ke-Tack (Korea Electrotechnology Research Institute) ;
  • Do, Jung-Yun (Department of Advanced Materials for Information and Display, Pusan National University)
  • Published : 2008.09.30
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Abstract

A simple and efficient synthesis of 3,4-dihydropyrimidinones or thiones is described, using silica-supported perchloric acid ($HClO_4-SiO_2$) as a heterogeneous catalyst from an aldehyde, $\beta$-dicarbonyl compound, and urea or thiourea under solvent-free conditions. Compared to the classical Biginelli reactions, this method consistently has the advantage of high yields, short reaction time, easy separation, and tolerance towards various functional groups.

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References

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