Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Antioxidant and antibacterial activities of Trema orientalis Linn: an indigenous medicinal plant of indian subcontinent

  • Uddin, Sarder Nasir (Department of Biology and Chemistry, Graduate School of Medicine, Yamaguchi University)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Methanol and aqueous extract of leaves of Trema orientalis Linn. were subjected to the potential antioxidant and antibacterial activities. The pharmacological interest of this plant coupled with traditional use (antidiarrhoeal, antiseptic, analgesic etc) prompted to test for antioxidant and antibacterial activities. The antioxidant potential of the methanolic extract was determined on the basis of their scavenging activity of the stable 1,1-diphenyl-2-picryl hydrazyl free radical. $IC_{50}$ of the methanol extract of T. orientalis was $110.25\;{\mu}g/ml$ which indicated the strong antioxidant activity of the plant. However the aqueous extract showed mild antioxidant activity. In case of antibacterial activities test, the extract was subjected for its effectiveness against both Gram-positive and Gram-negative bacteria in agar diffusion method. The zones of inhibition produced by the crude methanol and aqueous extract against few sensitive strains were measured and compared with those of standard antibiotic Gentamycin. It is evident that both extracts are active against the bacteria at low concentrations. The obtained results provide a support for the use of this plant in traditional medicine and suggest its further advance investigation.

Keywords

References

  1. Bauer AW, Kirby WMM, Sherris JC, Turck M. (1966) Antibiotic susceptibility testing by a standardized single disc method. Am. J. Clin. Pathol. 45, 493-496
  2. Farnsworth NR, Soejarto DD. (1991) Global importance of medicinal plants. In: Akerele O, Heywood V, Synge H. (Eds.) “The Conservation of Medicinal Plants”, Cambridge University Press, Cambridge, 25-51
  3. Gupta M, Mazumdar UK, Sivakumar T, Vamis MLM, Karkis S, Sambathkumar R, Mainkandan L. (2003) Antioxidant and Anti-inflammatory activities of Acalypha Fruticasa. Nig. J. Nat. Prod. Med. 25-29
  4. Halliwell H. (1994) Free radicals, antioxidants, and human disease: Curiosity, cause or consequence? Lancet 344, 721-724 https://doi.org/10.1016/S0140-6736(94)92211-X
  5. Halliwell B, Gutteridge JMC. (1985) Free radicals. In Biology and Medicine, $2^{nd}$ ed., Clarendron Press, Oxford, p.12-109
  6. Iwe MM. (1993) Hand Book of Medicinal Plants. CRC Publication. p. 251
  7. Kirtikar KR, Basu BD. (1980) Indian Medicinal Plants. 2nd Ed, Vol. 1, p. 264
  8. Larson RA. (1988) The antioxidants of higher plants. Phytochemistry 27, 969-978 https://doi.org/10.1016/0031-9422(88)80254-1
  9. Pelczar MJ, Chan JR, Noel ECS, Krieg KR. (1993) Microbiology. Fifth edition. Tata McGraw-Hill Publishing Company Ltd., New Delhi, India. pp.103-105, 510-539
  10. Rulangaranga ZK. (1991) Conservation of medicinal and aromatic plants in Tanzania proceedings of a workshop on priority species for tree planting and afforestation in Tanzania, Morogoro, Tanzania. May 14-18
  11. Sreejayan Rao MNA. (1997) Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49, 105-107
  12. Tripathi YB, Chaurasia S, Tripathi E, Upadhyay A, Dubey GP. (1996) Bacopa monniera Linn. As an antioxidant: Mechanism of action. Indian J. Exptl. Biol. 34, 523-526
  13. Uddin SN, Uddin KMA, Ahmed F. (2008) Analgesic and antidiarrhoeal activities of Treama orientalis Linn. in mice, Orient. Pharm. Exp. Med. 8, 187-191 https://doi.org/10.3742/OPEM.2008.8.2.187
  14. Uddin SN, Ali ME, Yesmin MN. (2008a) Antioxidant and Antibacterial Activities of Senna tora Roxb, Am. J. Plant Physiol. 3, 96-100
  15. Vani T, Rajani M, Sarkar S, Shishoo CJ. (1997) Antioxidant properties of the ayurvedic formulation Triphala and its constituents. Int. J. Pharmacog. 35, 313-317 https://doi.org/10.1080/09251619708951274

Cited by

  1. In vitro antiplasmodial activity and prophylactic potentials of extract and fractions of Trema orientalis (Linn.) stem bark vol.17, pp.1, 2017, https://doi.org/10.1186/s12906-017-1914-x
  2. Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis vol.15, pp.1, 2015, https://doi.org/10.1186/s12906-015-0643-2