Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Changes of Blood Chemistry by Experimental Cystic Duct Obstruction

실험적 담도폐색에 의한 혈액화학치의 변화

  • Lee, Hae-Beom (College of Veetrinary Medicine, Brain Korea 21, Bio-Safety Research Institute, Chonbuk National University) ;
  • Lee, Byung-Gon (Shinpung Animal Clinic) ;
  • Chon, Seung-Ki (Wow Animal Clinic) ;
  • Kim, Nam-Soo (College of Veetrinary Medicine, Brain Korea 21, Bio-Safety Research Institute, Chonbuk National University)
  • 이해범 (전북대학교 수의과대학, Post-BK21, 생체안전성연구소) ;
  • 이병곤 (신풍동물병원) ;
  • 전승기 (와우동물병원) ;
  • 김남수 (전북대학교 수의과대학, Post-BK21, 생체안전성연구소)
  • Published : 2008.10.31
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Abstract

The aim of this study was to establish an experiment animal model for easy diagnosis and monitoring effect of treatment of cholelithiasis by cholesterol and mixed gall stone. In 12 adult beagle dogs, five dogs there were in the control group and seven dogs in the experiment group with ligated cystic duct. General clinical signs were recorded, CBC and blood chemistry were examined. Control group and experiment group were evaluated every 2 weeks for a period of 20 weeks. The results were (1) Total blirubin, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity were significantly higher in the experiment group with ligated cystic duct than control group during 2-8 weeks. (2) Total alkaline phosphatase (TALP) activity was significantly higher when compare with control group during 2-8 weeks. Bone alkaline phosphatase(BALP) activity was increased slightly between 2 and 8 weeks but was decreased between 10 and 20 weeks. (3) Blood urea nitrogen (BUN) was decreased between 2 and 8 weeks. After 10 weeks, this was in normal range. (4) On complate blood count (CBC), $Ca^{2+}$ and P were not changed until 20 weeks. (5) On clinical signs in experimental group, they observed a depression, yellow color of mucus membrane and conjunctiva, xanthinuria and xanthochromic. The present study showed that the experimental animal model with ligated cystic duct was a useful model to study biliary tract disease.

Keywords

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