Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Relationship between Calcium/Inorganic Phosphorus and Parathyroid Hormone Concentrations in Dogs with Renal Failure

신부전증의 개에서 혈중 칼슘/무기인과 부갑상샘 호르몬의 관계

  • Kang, Dong-Joon (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lee, Soo-Han (Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Chung, Byung-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 강동준 (건국대학교 수의과대학 내과학교실) ;
  • 이수한 (울산대학교 의과대학 서울아산병원 임상약리학과) ;
  • 박희명 (건국대학교 수의과대학 내과학교실) ;
  • 정병현 (건국대학교 수의과대학 내과학교실)
  • Published : 2008.08.31
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Abstract

Parathyroid hormone (PTH) regulates calcium (Ca) and phosphate transport. Secondary hyperparathyroidism usually occur in chronic renal failure (CRF), and it is a common complication of CRF in dogs and cats. Twenty one dogs with renal failure were enrolled in this study. Plasma Ca, inorganic phosphorus (iP) and PTH concentrations were measured. Dogs were divided into two groups by the ratio of Ca to iP (Ca/iP$\leq$1; Group I, Ca/iP$\leq$1.5; Group II). The PTH level between sexes ages were not significantly different. The PTH level and Ca/iP between two groups were significantly different (p < 0.0001). In conclusion, The ratio of Ca to iP may be considered as useful surrogator to predict PTH level of dogs with renal failure.

부갑상샘 호르몬 (PTH)은 칼슘과 무기인의 수송을 조절한다. 속발성 부갑상샘 기능항진증은 대개 만성신부전에서 발생하고, 이는 개와 고양이에 있어서 CRF의 일반적인 합병증이다. 신부전을 갖는 21마리의 개가 본 연구에 사용되었다. 공시동물로부터 채혈한 혈액 중 칼슘 (Ca),무기인 (iP), PTH의 농도를 측정하여 칼슘과 무기인의 비율에 따라 두 군으로 분류하였다 (Ca / iP $\leq$ I; 그룹 1, Ca/ip $\geq$ 1.5; 그룹 II). 성과 연령 사이에 부갑상샘 호르몬 수준은 유의성 있는 차이가 없었다. 두 군 사이에 부갑상샘 호르몬 수준과 Ca/P의 비율에는 유의성 (p<0.0001)있는 차이가 나타났다. 결론적으로, 칼슘과 무기인의 비율은 신부전을 갖는 개에서 부갑상샘 호르몬 수준을 예측하기 위한 지표로 이용될 수 있을 것으로 생각된다.

Keywords

References

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