The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
권호 표지

Effect of Bobitang water extracts on immunosuppression induced by Methotrexate in SD rats

보비탕(補脾湯)이 methotrexate로 유발(誘發)된 흰쥐의 면역기능저하(免疫機能低下)에 미치는 영향(影響)

  • Cho, Hyun-Hee (Department of Pediatrics, college of Oriental Medicine, Daegu Haany University) ;
  • Yun, Hye-Jin (Department of Pediatrics, college of Oriental Medicine, Daegu Haany University) ;
  • Seo, Jung-Min (Department of Pediatrics, college of Oriental Medicine, Daegu Haany University) ;
  • Baek, Jung-Han (Department of Pediatrics, college of Oriental Medicine, Daegu Haany University)
  • 조현희 (대구한의대학교 한의과대학 소아과학교실) ;
  • 윤혜진 (대구한의대학교 한의과대학 소아과학교실) ;
  • 서정민 (대구한의대학교 한의과대학 소아과학교실) ;
  • 백정한 (대구한의대학교 한의과대학 소아과학교실)
  • Published : 2007.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : In order to investigate the effect of Bobitang on SD rats with deteriorated immunity caused by methotrexate. Methods : The test sample were dosed once a day for 14 days by gastric gavage at a dosage 1,000, 500 and $250mg/kg/10m{\ell}$ from 2 days after last MTX-dosing, and the changes on body weight and gains, spleen weight and total blood leukocyte numbers, total lymphocyte numbers, the percentage of B-cell, T-cell, CD3+CD4+ T-cell, CD3+CD8+ T-cell and CD4+/CD8+ T-cell ratios in the blood and spleen were observed. Results : The changes on body weight gains, the spleen weight, the total blood leukocyte numbers, the total lymphocyte numbers in the blood and spleen, the ratio of T-cell in the blood and spleen, the ratio of CD3+CD4+ T-cell in the blood and spleen were increased significantly in BBT Extracts groups as compared with control group. The ratio of B-cell in the blood and spleen was not increased significantly in BBT Extracts groups as compared with control group. The percentage of CD3+CD8+ T-cell in the blood and spleen was decreased significantly in BBT Extracts groups as compared with control group. The ratio of CD4+/CD8+ T-cell in blood and spleen was increased significantly in BBT Extracts group as compared with control group. Conclusions : According to the above results, Bobi-Tang has an effect of increasing immune responses on SD rats with deteriorated immunity caused by methotrexate.

Keywords