The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Ethanol extract of Bojungbangam-tang (EBJT) prevents Cisplatin-induced Apoptosis in mice.

시스플라틴의 세포고사에 대한 보정방암탕 에탄올 추출물의 효과

  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Jeon, Byung-Hun (Dept. of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Sung-Hoon (Dept. of Oriental Pathology, College of Oriental Medicine, Kyunghee University) ;
  • Ahn, Kyoo-Seok (Dept. of Oriental Pathology, College of Oriental Medicine, Kyunghee University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 김성훈 (경희대학교 한의과대학 한방병리학교실) ;
  • 안규석 (경희대학교 한의과대학 한방병리학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실)
  • Published : 2007.03.30
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Abstract

Objectives : The purpose of this study is to investigate cisplatin-induced apoptosis by ethanol extract of bojungbangam-tang (EBJT). Methods : To evaluate of anti-apoptic effects of EBJT, we examined several kinds of cell populations such as $CD4^{+}$ T cells, $CD8^{+}$ T cells and macrophages in spleen. Result : 1. EBJT inhibited cisplatin-induced cell death in spleen. 2. EBJT inhibited the death of $CD4^{+}$ and $CD8^{+}$ T cells. 3. EBJT slightly recovered the number of macrophages by cisplatin. Furthermore, cisplatin-induced upregulation of class II were inhibited by EBJT. Conclusion : EBJT prevented cisplatin-induced cell death, which could provide a clinical basic for side effects of anti-tumor therapeutics.

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