The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 1
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- Pages.81-87
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Effect of Angelicae Dahuricae Radix on Expression of Cytokines and Chemokines Levels in Human Mast Cells (HMC)
백지의 사람비만세포 사이토카인 및 케모카인 발현 양상
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Kim, Myung-Gyou
(College of Pharmacy, Woosuk University) ;
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Lee, Se-Na
(College of Korean Medicine, Semyung University) ;
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Lim, Jong-Pil
(College of Pharmacy, Woosuk University) ;
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Leem, Kang-Hyun
(College of Korean Medicine, Semyung University)
- Published : 2007.03.30
Abstract
Objectives: Angelicae Dahuricae Radix (Baek-Ji in Korean, BJ) is well known to be used as a medicine for cold, headache, supraorbital pain, nasal congestion, and toothache. Little is understood about the roles of BJ in the cytokine and chemokine secretion by immune cells. This study was designed to find out the effects of BJ on the cytokine and chemokine secretion in human mast cells (HMC). Methods : We treated BJ according to consistency on HMC and measured cytokines and chemokines levels using flow cytometry CBA system. Results: In BJ treated group. the expression of interferon-inducible protein 10 (IP-l0), monocyte chemoattractant protein-1 (MCP-1), chemokine (C-X-C motif) ligand 9 (MIG), and interleukin 10 (IL-l0) levels were decreased significantly and chemokine (C-C motif) ligand 5 (RANTES), IL-8,