Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects of Gagambosim-Tang of focal brain ischemic injury induced by Intraluminal Filament insertion in the rats

가감보심탕(加減補心湯)의 구강투여가 Intraluminal Filament 삽입술(揷入術)에 의(依)해 유발(誘發)된 백서(白鼠)의 허혈성(虛血性) 뇌손상(腦損傷)에 미치는 영향(影響)

  • Ryu, Seung-Jun (Dept. of Neuropsychiatry, college of Oriental Medicine, Wonkwang University) ;
  • Lee, Chung-Sik (Dept. of Neuropsychiatry, college of Oriental Medicine, Wonkwang University) ;
  • Park, Bo-Ra (Dept. of Neuropsychiatry, college of Oriental Medicine, Wonkwang University) ;
  • Seo, Jong-Hoon (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Hyung-Won (Dept. of Neuropsychiatry, college of Oriental Medicine, Wonkwang University) ;
  • Lyu, Yeong-Su (Dept. of Neuropsychiatry, college of Oriental Medicine, Wonkwang University) ;
  • Kim, Tae-Heon (Dept. of Neuropsychiatry, college of Oriental Medicine, Wonkwang University)
  • 류승준 (원광대학교 한의과대학 한방신경정신과 교실) ;
  • 이충식 (원광대학교 한의과대학 한방신경정신과 교실) ;
  • 박보라 (원광대학교 한의과대학 한방신경정신과 교실) ;
  • 서종훈 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과 교실) ;
  • 류영수 (원광대학교 한의과대학 한방신경정신과 교실) ;
  • 김태헌 (원광대학교 한의과대학 한방신경정신과 교실)
  • Published : 2007.03.30
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Abstract

Objective : The aim of this study was to investigate effects of Gagambosim-Tang(GBT) of focal brain ischemic injury induced by intraluminal filament insertion in the rats. Method : The ischemia was induced by intraluminal filament insertion into middle cerebral artery Eight-arm radial maze was designed for the behavioral task. Gagambosim-Tang was orally administrated in SD rats for 21 days. The task was started on the 4th week after focal brain injury, and performed two trials per day for 6days. The effects of Gagambosim-Tang on neuroprotective agents in cresyl violet, choline acetyltranferase(ChAT), nerve growth factor (NGF)-stain and c-Fos with ischemic injury were investigated. Results : The errors in the eight-arm radial maze task were significantly decreased in normal group compared with control group on 2-6days, GBT lX(42.2 mg/ml)orally administrated group on 1days, GBT 6X(253.2 mg/ml) on 3, 5, 6days. The rate of correct choice was increased in normal and GBT 6X groups. The neuroprotective effect in the hippocampal CA1 was increased in normal and GBT 1X, GBT 6X groups compared with control group. The density of ChAT in the hippocampal CA1 was increased in normal and GBT6X groups compared with control group. The density of NGF in the hippocampal CA1 was increased normal and GBT6X groups compared with control group. The number of c-Fos-positive neurons in the hippocampal CA1 was increased in normal and GBT 6X groups compared with control group. Conclusion : These results suggest that Gagambosim-Tang may have protective effect on dementia.

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