Natural Product Sciences

  • 제13권3호
  • /
  • Pages.251-254
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  • 2007
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived Fungus Pseudallescheria sp.

  • Zhang, Dahai (Department of Chemistry, Pukyong National University) ;
  • Noviendri, Dedi (Department of Chemistry, Pukyong National University) ;
  • Nursid, Muhammad (Department of Chemistry, Pukyong National University) ;
  • Yang, Xiu-Dong (Department of Chemistry, Pukyong National University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • 발행 : 2007.09.30
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초록

Dioxopiperazine alkaloids, 12R,13S-dihydroxyfumitremorgin C (1), fumitremorgin C (2), and brevianamide F (3), were isolated from the marine-derived fungus Pseudallescheria, and the absolute stereostructures of compounds 1 - 3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1 - 3 showed an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC (minimum inhibitory concentration) values of compounds 1 - 3 were 125 ${\mu}g/mL$ for all strains.

키워드

참고문헌

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