Journal of the Korean Society of Food Culture (한국식생활문화학회지)

Korean Society of Food Culture (한국식생활문화학회)
권호 표지
DOI QR코드

DOI QR Code

Comparisons of UCP2 Polymorphism, Dietary Habits, and Obesity Index in Normal and Obese University Students

정상체중과 비만인 대학생의 UCP 2 유전자 다형성, 식습관, 비만도 및 체성분의 비교 연구

  • Ahn, Myoung-Soo (Gwangju Samsung Medical Center) ;
  • Chang, In-Youb (Korea DNA Repair Research Center Dept of Anatomy, School of Medicine, Chosun University) ;
  • Kim, Kyung-Hee (Food and Nutrition, Division of Human Ecology, Mokpo National University)
  • Published : 2007.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was carried out to compare UCP2 polymorphism, dietary habits, and obesity index in normal and obese university students. The survey was carried out using self-questionnaires collected from the 126 normal and 60 obese university students. The results are summarized as follows. Breakfast was skipped in 43.7% of normal and 49.3% of obesity students and it appeared obese students eat faster than normal students. The percentage of weight control experience were 49.2 and 71.0 in the normal and obese students, respectively. Blood levels of lipid profiles(triglyceride, LDL cholesterol, and HDL cholesterol), hemoglobin, AST and ALT were anaylzed. In UCP2 genes, the frequency of deletion homozygote(DD) was 71.5%, heterozygote(DI) was 26.9% and insertion homozygote(II) was 1.6%. Plasma levels of triglyceride, total cholesterol, LDL cholesterol, and HDL cholesterol of normal students were 79.06, 172.25, 100.86 and 57.03 mg/dl, and those of obese students were 93.06, 173.22, 101.22 and 54.39 mg/dl, respectively. Blood parameters were in normal range in both group. Plasma triglyceride, total cholesterol and LDL cholesterol levels of obese students were higher than those of normal students. On the other hand, plasma HDL cholesterol levels of obese students were lower than those of normal students. Plasma levels of AST and ALT were in normal range in both group. However, AST and ALT levels of obese students were higher than that of normal students. Thus, it was recommended for them to have a nutritional education program to improve their dietary and living habits for obese students’health. Nutritional education program should also be organized practically and systematically.

Keywords

References

  1. Bak AAA, Grobbee DE. 1989. The effect on serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med, 321(21): 1432-1437 https://doi.org/10.1056/NEJM198911233212103
  2. Benhamou D, Cuvelier A, Muir JF, Leclerc V, Le Gros V, Kottakis J, Bourdeix I. 2001. Rapid onset of bronchondilation in COPD : a placebo-controlled study comparing formoterol (Foradil Aerolizer) with salbutamol(Ventodisk). Respir Med, 95(10): 817-821 https://doi.org/10.1053/rmed.2001.1161
  3. Bray GA.Obesity. In Fauci AS, Baunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hause SL, Longo DL eds. 1998. Harrison's Principles of Internal Medicine. New York, McGraw-Hill. 454-462
  4. Buemann B, Schierning B, Toubro S, Bibby BM, Sorensen T, Dalafard L, Pedersen O, Astrup A. 2001. The association between Val/Ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency. Int J Obes, 25: 467-471 https://doi.org/10.1038/sj.ijo.0801564
  5. Chung NY, Yoon ME, Choi SN. 2002. A study on the dietary behavior and the food habits of university freshman according to body mass index. Korean J Dietary Culture, 17(4): 387-398
  6. Comuzzie AG, Allison DB. 1998. The search of human obesity genes. Science, 280: 1374-1377 https://doi.org/10.1126/science.280.5368.1374
  7. Elisaneth W, Markku L, Timo K, Jeremy W, Alsan RS, Lief CG. 1999. Association of a polymorphism in the ${\beta}3$-adrenergic receptor gene with features of the insulin resistance syndrome in Finns. The England Journal of Medicine 333: 348-351
  8. Heckers H, Gobel U, Kleppel U. 1994. End of the coffee mystery: diterpene alcohols raise serum low-density lipoprotein cholesterol and triglyceride levels. J Intern Med, 235(2): 192-193 https://doi.org/10.1111/j.1365-2796.1994.tb01058.x
  9. Hong SM, Bak KJ, Jung SH, Oh KW, Hong YA. 1993. A study on nutrient intakes and hematological status of female college students of Ulsan city. Korean J Nutr, 26(3): 338-346
  10. Hubert HB, Feinleib M, McNamara PM, Castelli WP. 1983. Obesity as independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart study. Circulation, 67: 968-977 https://doi.org/10.1161/01.CIR.67.5.968
  11. Hyun WJ. 2001. The relationship between obesity, lifestyle, and dietary intake and serum lipid level in male university students. Korean J Comm Nutr, 6(2): 162-171
  12. Jack AY, Adam LD, Kera NS, Hongzhe Lin, Nancy GS, Craig HW. 2000. Associations between uncoupling protein 2, body composition and resting energy expenditure in lean and obese African American, white, and Asian children. Am J Clin Nutr, 71: 140-142
  13. Jahan H, Odette P, Anders T, Fredrik L, Stefan MH, Fancois C, Peter Arner. 1999. Polymorphism of the Human ${\beta}3$-adrenoreceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function. Diabetes 48: 203-205 https://doi.org/10.2337/diabetes.48.1.203
  14. Jung BM, Oh ES, Choi SM, Cha YS. 2001. Survey of alcoholic and non-alcoholic beverage preference in college students of the Chonnam area. Korean J Comm Nutr, 6(3): 290-296
  15. Kim BR, Han YB, Chang UJ. 1997. A study on the attitude toward control, diet behavior and food habits of college students. Korean J Comm Nutr, 2(4): 530-538
  16. Kim BR, Im YS. 1998. A study on the food habits of college students by body mass index. Korean J Comm Nutr, 3(1): 44-52
  17. Kim HS, Suh ES, Shin MK. 1996. A study on the food behaviors of college students in chonbuk area. J of the East Asian of Dietary life, 6(2): 153-166
  18. Kim HD, Kim DS, Kim SS. 1994. Milk and beverage preference of college students. J Korean Soc Food Nutr, 23(3): 420-428
  19. Kim IS, Yu HH, Han HS. 2002. Effects of nutrition knowledge, dietary attitude, dietary habits and life style on the health of college students in the Chungnam area. Korean J Comm Nutr, 7(1): 45-57
  20. Kim JH, Lee WS, Mun JS, Kim KW. 1997. A study on dietary intakes and nutritional status in college women smokers- I.Anthropometric measurements and nutient intakes. Korean J Comm Nutr, 2(1): 33-43
  21. Kluas S, Casteilla L, Bouilland F, Ricquider D. 1991. The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int J Biochem, 23: 791-801 https://doi.org/10.1016/0020-711X(91)90062-R
  22. Klannemark M, Orho M, Groop L. 1998. No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure. European Journal of endocrinology, 139: 217-223 https://doi.org/10.1530/eje.0.1390217
  23. Klingenber M. 1990. Mechanism and evolution of the uncoupling protein of brown adipose tissue. Trends Biochem Sci, 15: 108-112 https://doi.org/10.1016/0968-0004(90)90194-G
  24. Kwon SH, Kim YS, Lee HS. 2003. Community Nutrtion. Hyoil publishing company. pp 296-308
  25. Lee HJ, Cho KY. 1995. A study on dietary behavior and health status of Korean middle school students. The Journal of Korean Living Science Research, 13(13): 17-55
  26. Lee HB, Yu YS. 1995. A study on lunch meal practice of the college students in Seoul area. The Korean Society of Dietary Culture, 10(3): 147-154
  27. Lee HS, Lee JA, Paik JJ. 1998. A study of food habits, physical status and related factors of college students in Chuncheon. Korean J Comm Nutr, 3(1): 34-43
  28. Lee KW, Lee YM. 1995. Nutritional knowledge, attitude and behavior of college students in Seoul and Kyunggido area. The Korean Society of Dietary Culture, 10(2): 125-132
  29. Lee YN, Choi HM. 1994. A study on the relationship between body mass index and the food habits of college students. The Korean Society of Dietary Culture, 9(1): 1-10
  30. Ministry of Health & Welfare. 1999. National Health and Nutrition Survey
  31. Mitchell P. 1979. Keilins respiratory chain concept and its chemiosomotic consequences. Science, 206: 1148-1159 https://doi.org/10.1126/science.388618
  32. Montenson GM, Hoerr SL, Garner DM. 1993. Predictors of body satisfaction in college women. Am Diet Asso, 93(9): 1037-1039 https://doi.org/10.1016/0002-8223(93)92044-X
  33. National Statistical Office. 2001. Annual report of the cause of death statistics(2000)
  34. Nocholls DG, Locke RM. 1984. Thermogenic mechanism in brown fat. Physiol Rev, 64: 1-64 https://doi.org/10.1152/physrev.1984.64.1.1
  35. Park HR. 1996. Current nutrtional status by different age group. Korean J Comm Nutr 1(2): 301-322
  36. Park YS, Lee YW, Hyun YS. 1995. Comparison of dietary behaviors by type of residence among college students. Korean J Dietary Culture, 10(5): 391-404
  37. Pizzuti A, Gnavi R, Testa MA, Antonielli E, Bassignana A, Rovere ME, Abogadri E, Di Leo M. 2001. Cardiovascular risk factors in a community in Piedmont : changes after 11 years and a comparison with other regional and national data. Ital Heart J, 2(9 suppl): 1005-1010
  38. Rehm J, Greenfield TK, Rogers JD. 2001. Average volume of alcohol consumption, patterns of drinking, and all-cause mortality : results from the US National Alcohol Survey. Am J Epidemiol, 153(1): 64-71 https://doi.org/10.1093/aje/153.1.64
  39. Rogers AE, Conner MW. 1986. Alcohol and cancer. Adv Exp Med Biol, 206: 473-495
  40. Rolfe DFS, Brown GC. 1997. Cellular-energy utiliation and molecular-origin of standard metabolic rate in mammals. Physiol Rev, 77: 731-758 https://doi.org/10.1152/physrev.1997.77.3.731
  41. Ryu HK, Yoon JS. 2000. Comparative study of nutrient intakes and health status with body size and weight control experience in adolescent females. Korean J Comm Nutr, 5(3): 444-451
  42. Salaspuro M. 1993. Nutrient intake and nutritional status in alcoholics. Alcohol, 28(1): 85-88
  43. Shinton R. 1997. Lifelong exposures and the potential for stroke prevention : the contribution of cigarette smoking, exercise, and body fat. J Epidemiol community Health, 51(2): 138-143 https://doi.org/10.1136/jech.51.2.138
  44. Stankard AJ. 1996. Current views on obesity. Am J Med, 100: 230-236 https://doi.org/10.1016/S0002-9343(97)89464-8
  45. Stankard AJ, Sorensen TI, Hanis C, Teasdale TW, Chakraborty R, Schull WJ, Schulsinger F. 1986. An adoption study of human obesity. N Engl J Med, 314: 193-198 https://doi.org/10.1056/NEJM198601233140401
  46. Tomoko s, Tadashi S, Yukio I, Mari I, Toshihiro N, Yoshitaka K, Yuh N, Kozo H. 1999. Screening for variants of the uncoupling protein 2 gene in Japanese patients with noninsulin- dependent diabetes mellitus. Metabolism, 48: 581-584 https://doi.org/10.1016/S0026-0495(99)90054-9
  47. Urgert R, Meyboom S, Kuilman M. 1996. Comparison of the effect of cafetiere and filtered coffee on serum concentrations of liver aminotransferases and lipids : six month randomised controlled trial. BMJ, 313: 1362-1366 https://doi.org/10.1136/bmj.313.7069.1362
  48. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. 1997. UCP3 : an uncoupling protein hoologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys. Res. Commun, 235: 79-82 https://doi.org/10.1006/bbrc.1997.6740
  49. Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Silver MH, Shuldiner AR. 1998. Association between uncoupling protein polymorphism (UCP2-UCP3) and energy metabolism/obesity in Pima indians. Hum Mol Genet Sep, 7(9): 1431-1435 https://doi.org/10.1093/hmg/7.9.1431
  50. Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S. 1995. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the ${\beta}-3$-adrenergic receptor gene. New England Journal of Medicine, 333: 343-347 https://doi.org/10.1056/NEJM199508103330603
  51. WHO West Pacific Region. 2000. The Asia-pacific perspective : Refining obesity and its treatment
  52. Yanovski JHA, Diament KN, Sovik TT, Nguyen H, Sevring CH, Warden. 2002. Associations between uncoupling protein 2, body composition and resting energy expenditure in lean and obese African American, White and Asian children. Am J Clin Nutr, 71: 1405-1420