The Journal of Korean Medicine (대한한의학회지)
- Volume 28 Issue 2 Serial No. 70
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- Pages.166-184
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- 2007
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
Effects of Daegeum-eumja, Igwi-tang and Sihosogan-san on Gastric Mucosal Lesions Induced by Alcohol, Indomethacin and Burn-stress in Mice.
Alcohol, Indomethacin 및 Burn-stress로 유발된 생쥐의 위점막 손상에 대한 대금음자(對金飮子), 익위탕(益胃湯), 시호소간산(柴胡疎肝散)의 효과
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Kong, Kyung-Hwan
(Department of Internal Medicine, College of Oriental Medicine, Semyung University)
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공경환
(세명대학교 한의과대학 비계내과학교실)
- Published : 2007.06.30
Abstract
Objectives : This study was conducted to investigate the effects of Daegeum-eumja, Igwi-tang, and Sihosogan-san on gastric mucosal lesions induced by alcohol, indomethacin, and burn-stress in mice. Methods : Experimental mice were divided into six groups. The normal group (NOR) did not receive any treatment to elicit gastropathy. In the control group (GE), gastropathy was elicited by alcohol, indomethacin, and stress. In the misoprostol group (MS), misoprostol was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Daegeum-eumja group (DG), Daegeum-eumja was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Igwi-tang group (IW), Igwi-tang was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Sihosogan-san group (SH), Sihosogan-san was administered after gastropathy waselicited by alcohol, indomethacin, and stress. The effects on gastric mucosal lesions were evaluated by the morphological change of gastric mucosa, the anti-oxidant effect, HSP 70,