YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Urea and Thiourea Derivatives and Their Inhibitory Activities of NO Production by Activated Macrophages

유레아 및 티오유레아 유도체의 합성과 활성화된 대식세포의 NO 생성 저해효과

  • Kim, Yoon-Jung (College of Pharmacy Sookmyung Women's University) ;
  • Cheon, Ye-Jin (College of Pharmacy Sookmyung Women's University) ;
  • Lim, Hyo-Jin (College of Pharmacy Sookmyung Women's University) ;
  • Ryu, Jae-Ha (College of Pharmacy Sookmyung Women's University) ;
  • Jeon, Ra-Ok (College of Pharmacy Sookmyung Women's University)
  • 김윤정 (숙명여자대학교 약학대학) ;
  • 천예진 (숙명여자대학교 약학대학) ;
  • 임효진 (숙명여자대학교 약학대학) ;
  • 류재하 (숙명여자대학교 약학대학) ;
  • 전라옥 (숙명여자대학교 약학대학)
  • Published : 2007.08.31
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Abstract

Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 ${\mu}M$ of $IC_{50}$ value.

Keywords

References

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