Epidemiological Characterization of Influenza Virus Isolated from Acute Respiratory Illness in Busan, 2004-2005

최근 2년간 부산지역에서 급성호흡기 환자로부터 분리한 인플루엔자바이러스의 유행 양상

  • Cho, Kyung-Soon (Epidemiology Division, Busan Metropolitan City Institute of Health & Environment) ;
  • Park, Sun-Mee (Epidemiology Division, Busan Metropolitan City Institute of Health & Environment) ;
  • Kim, Seang-Joon (Epidemiology Division, Busan Metropolitan City Institute of Health & Environment) ;
  • Jung, Myung-Ju (Department of Biology, Kyung Sung University) ;
  • Lee, Joo-Yeon (Division of Influenza and Respiratory Viruses, National Institute of Health, Korea Center for Disease Control and Prevention) ;
  • Kang, Chun (Division of Influenza and Respiratory Viruses, National Institute of Health, Korea Center for Disease Control and Prevention)
  • 조경순 (부산광역시 보건환경연구원 역학조사과) ;
  • 박선미 (부산광역시 보건환경연구원 역학조사과) ;
  • 김성준 (부산광역시 보건환경연구원 역학조사과) ;
  • 정명주 (경성대학교 생물학과) ;
  • 이주연 (질병관리본부 국립보건연구원 인플루엔자바이러스팀) ;
  • 강춘 (질병관리본부 국립보건연구원 인플루엔자바이러스팀)
  • Published : 2007.09.30

Abstract

The occurrence of acute respiratory infections caused by the influenza virus are particularly high during the winter season in Busan, Korea. In 2004 and 2005, a study of the rate of occurrences of the influenza virus was conducted. The results reveal that in 2004, of the 1,869 people with an acute respiratory infection that 154 (8.2%) people were infected by the influenza virus. In 2005, of the 1,579 people infected with an acute respiratory infection that 19 people (1.2%) were infected with the influenza virus. The study shows a decrease in the numbers of an influenza virus infection from 2004 to 2005. Data was collected by inspecting throat swabs and nasal discharge from those with an acute respiratory infection. Further inspection of the throat swab and nasal discharge from the infected individuals during 2004 and 2005 study show the occurrence of the different types of influenza virus in the population: 6 cases (3.5%) of influenza type A/H1N1, 129 cases (74.5%) of A/H3N2, and 38 cases (22.0%) of type B. The study conducted in 2004 and 2005 reveal that children between the ages of two and five were more likely to be infected than any other age group. In the study, about 62.2% of the infected individuals were between two and five years old. The detection rates between males and females are similar. However, it is notable that females are slightly more likely to develop an acute respiratory infection caused by the influence virus compared to their male counterparts.

2004년과 2005년 동안 부산지역에서 급성호흡기환자로부터 인플루엔자바이러스를 분리 동정하여 분식한 결과, 인플루엔자바이러스분리율은 2004년도는 1869건의 호흡기 검체 중 인플루엔자바이러스 154건 중, A/H3N2형은 77.3%에 해당하는 119건, B형의 경우 35건(22.7%)으로 나타났고 A/H1N1형은 검출되지 않았다. 분리된 인플루엔자바이러스의, 2005년의 경우 1579건의 호흡기 검체 중에서 분리된 인플루엔자바이러스 19건 중, A/H1N1형은 6건(31.6%) 검출되었으며, A/H3N2형은 52.6%에 해당하는 10건, B형의 경우는 3건(15.8%)으로 나타났다. 2005년의 경우 전체적인 인플루엔자바이러스 분리율은 2004년에 비해 떨어졌으나, A/H3N2의 경우 여전히 높은 분리율을 보였으며 2004년에는 전혀 검출되지 않았던 A/H1N1이 B형보다 많이 분리되었다. 부산지역에서 분리된 바이러스의 항원형을 분석한 결과 당해연도 백신주와 동일하거나 유사하였다. 연령별 발생 분포는 0-10세 이하에서 80-90%이상을 차지하였고, 남성에 비해 여성에서 약간 높은 분리율을 나타내었다. 월별 분리율은 2004년도는 4월, 2005년도는 2월이 가장 많이 분리되었다. 인플루엔자바이러스의 대유행 주기에 임박한 현 시점에서 지속적으로 인플루엔자유행예측조사로서 조기 분리한 인플루엔자바이러스 주를 유전자 염기서열을 분석함으로써 신종 인플루엔자바이러스가 출현되는지 적극적인 감시가 필요하다.

Keywords

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