Food Science and Biotechnology

  • 제16권3호
  • /
  • Pages.463-469
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  • 2007
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  • 1226-7708(pISSN)
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  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

Effect of Colored Potato Flakes Against Acetaminophen-induced Liver Damage in Rats

  • Ohba, Kiyoshi (Hokkaido Tokachi Area Regional Food Processing Technology Center) ;
  • Watanabe, Shoko (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine) ;
  • Han, Kyu-Ho (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine) ;
  • Hashimoto, Naoto (Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region) ;
  • Noda, Takahiro (Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region) ;
  • Shimada, Ken-Ichiro (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine) ;
  • Tanaka, Hisashi (Somatech Center, House Foods Corporation) ;
  • Sekikawa, Mitsuo (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine) ;
  • Fukushima, Michihiro (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine)
  • 발행 : 2007.06.30
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초록

We examined the hepatoprotective effects of colored potato flakes on acetaminophen (AAP)-induced liver damage in rats. F344/DuCrj (8 week-old) rats were fed a cholesterol-free diet with 54.9486 g of ${\alpha}$-corn starch/100g diet and were orally treated with 25% colored flakes of Kitamurasaki (KM: light purple), Northern Ruby (NR: red), and Shadow Queen (SQ: medium purple) potatoes co-administered with AAP (0.5 g/100 g diet) for 4 weeks. The hepatic thiobarbituric acid-reactive substances (TBARS) values in the KM, NR, and SQ groups were significantly lower (p<0.05) than those in the control groups with and without AAP. Furthermore, the hepatic catalase, Mn-superoxide dismutase (SOD), and Cu/Zn-SOD mRNA levels in the KM, NR, and SQ groups were higher than those in the control groups with and without AAP. The present findings suggest that colored potato flakes are useful as a prophylactic agent against oxidative liver damage.

키워드

참고문헌

  1. Thomas SHL. Paracetamol (acetaminophen) poisoning. Pharmacol. Therapeut. 60: 91-120 (1993) https://doi.org/10.1016/0163-7258(93)90023-7
  2. Gregus Z, Madhu C, Klaassn CD. Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites. J. Pharmacol. Exp. Ther. 244: 91-99 (1988)
  3. Jeon JR, Choi JH. Effect of ash tree leaf extract on acetaminophen-induced hepatotoxicity in mice. Food Sci. Biotechnol. 15: 752-755 (2006)
  4. Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-Acetyl-p-benzo-quinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. P. Natl. Acad. Sci. USA 81: 1327-1331 (1984)
  5. Mitchell DB, Acosta D, Bruckner JV. Role of glutathione depletion in the cytotoxicity of acetaminophen in a primary culture system of rat hepatocytes. Toxicology 37: 127-146 (1985) https://doi.org/10.1016/0300-483X(85)90119-2
  6. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. P. Natl. Acad. Sci. USA 90: 7915-7922 (1993)
  7. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J. Am. Diet Assoc. 96: 1027-1039 (1996) https://doi.org/10.1016/S0002-8223(96)00273-8
  8. Renaud S, de Logeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339: 1523-1526 (1992) https://doi.org/10.1016/0140-6736(92)91277-F
  9. Wang H, Nair MG, Strasburg GM, Chang YC, Booren AM, Gray JI, DeWitt DL. Antioxidant and anti-inflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J. Nat. Prod. 62: 294-296 (1999) https://doi.org/10.1021/np980501m
  10. Oh JK, Kim SJ, Imm JY. Antioxidative effect of crude anthocyanin in water-in-oil microemulsion system. Food Sci. Biotechnol. 15: 283-288 (2006)
  11. Han KH, Fukushima M, Ohba K, Shimada K, Sekikawa M, Chiji H, Lee CH, Nakano M. Hepatoprotective effects of the water extract from adzuki bean hulls on acetaminophen-induced damage in rat liver. J. Nutr. Sci. Vitaminol. 50: 380-383 (2004) https://doi.org/10.3177/jnsv.50.380
  12. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951 (1993) https://doi.org/10.1093/jn/123.11.1939
  13. Han KH, Sekikawa M, Shimada K, Hashimoto M, Hashimoto N, Noda T, Tanaka H, Fukushima M. Anthocyanin-rich purple potato flake extract has antioxidant capacity and improves antioxidant potential in rats. Brit. J. Nutr. 96: 1125-1133 (2006) https://doi.org/10.1017/BJN20061928
  14. National Research Council. Guide for the Care and Use of Laboratory Animals. Publication no. 85-123 (rev.), National Institute of Health, Bethesda, MD, USA (1985)
  15. Miyazawa T, Fujimoto K, Suzuki T, Yasada K. Determination of phospholipid hydroperoxide using luminol chemiluminescencehigh- performance liquid chromatography. Methods Enzymol. 233: 324-332 (1994) https://doi.org/10.1016/S0076-6879(94)33037-9
  16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275 (1951)
  17. Han KH, Fukushima M, Kato T, Kojima M, Ohba K, Shimada K, Sekikawa M, Nakano M. Enzyme-resistant fractions of beans lowered serum cholesterol and increased sterol excretions and hepatic mRNA levels in rats. Lipids 38: 919-924 (2003) https://doi.org/10.1007/s11745-003-1145-2
  18. Kano M, Takayanagi T, Harada K, Makino K, Ishikawa F. Antioxidative activity of anthocyanins from purple sweet potato, lpomoera batatas cultivar ayamurasaki. Biosci. Biotech. Bioch. 69: 979-988 (2005) https://doi.org/10.1271/bbb.69.979
  19. Oda H, Suzuki Y, Shibata T, Yoshida A. Glucocorticoid-dependent induction of HMG-CoA reductase and malic enzyme gene expression by polychlorinated biphenyls in rat hepatocytes. J. Nutr. Biochem. 10: 644-653 (1999) https://doi.org/10.1016/S0955-2863(99)00055-8
  20. Kishimoto M, Kamasaka H, Murakami A, Kawaguchi M, Matsuura T, Okada S, Ichikawa T. Effect of phosphorylated oligosaccharide from potato-starch on calcium absorption in rats. J. Jpn. Soc. Nutr. Food Sci. 51: 67-72 (1998) https://doi.org/10.4327/jsnfs.51.67
  21. Tsuda T, Horio F, Osawa T. Dietary cyanidin 3-o-$\beta$-D-glucoside increases ex vivo oxidation resistance of serum in rats. Lipids 33: 583-588 (1998) https://doi.org/10.1007/s11745-998-0243-5
  22. Tsuda T, Horio F, Kitoh J, Osawa T. Protective effects of dietary cyanidin 3-o-$\beta$-D-g1ucoside on liver ischernia-reperfusion injury in rats. Arch. Biochem. Biophys. 368: 361-366 (1999) https://doi.org/10.1006/abbi.1999.1311
  23. Ohba K, Nirei M, Watanabe S, Han KH, Hashimoto N, Shimada K, Sekikawa M, Chiji H, Fukushima M. Eifect of an adzuki bean extract on hepatic anti-oxidant enzyme mRNAs in D-galactosamine treated rats. Biosci. Biotech. Bioch. 69: 1988-1901 (2005) https://doi.org/10.1271/bbb.69.1988
  24. Shen XC, Qian ZY. Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats. Pharmazie 61: 348-352 (2006)
  25. Yokozawa T, Cho EJ, Nakagawa T. Influence of green tea polyphenol in rats with arginine-induced renal failure. J. Agr. Food Chem. 51: 2421-2425 (2003) https://doi.org/10.1021/jf021046+
  26. Yeh CT, Yen GC. Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 mRNA expression. J. Nutr. 136: 11-15 (2006)
  27. Cardador-Martinez A, Loarca-Pina G, Oomah BD. Antioxidant activity in common beans (Phaseolus vulgaris L.). J. Agr. Food Chem. 50: 6975-6980 (2002) https://doi.org/10.1021/jf020296n