Metabolite Analysis of Panax ginseng C. A. Meyer by HPLC According to Root Age

  • Shin, Yoo-Su (Ginseng and Medicinal Crops Division, National Institute of Crop Science, RDA) ;
  • Lee, Min-Jeong (Ginseng and Medicinal Crops Division, National Institute of Crop Science, RDA) ;
  • Bang, Kyong-Hwan (Ginseng and Medicinal Crops Division, National Institute of Crop Science, RDA) ;
  • Kim, Seon-Young (College of Agriculture and Life Sciences, Seoul National University) ;
  • Lee, Sung-Sik (KT&G Central Research Institute) ;
  • Hyun, Dong-Yoon (Ginseng and Medicinal Crops Division, National Institute of Crop Science, RDA) ;
  • An, Tae-Jin (Ginseng and Medicinal Crops Division, National Institute of Crop Science, RDA) ;
  • Cha, Seon-Woo (Ginseng and Medicinal Crops Division, National Institute of Crop Science, RDA) ;
  • Seong, Nak-Sul (Ginseng and Medicinal Crops Division, National Institute of Crop Science, RDA)
  • Published : 2007.08.31

Abstract

In order to investigate the major metabolite patterns of aged Panax ginseng C.A. Meyer roots, the ginsenoside contents for white ginseng roots of various ages were compared. The 1-year to 6-year old roots were extracted with methanol, and then the methanol-soluble metabolites were analyzed by high performance liquid chromatography (HPLC). The metabolite contents of the 1-year and 2-year roots, including the ginsenosides and minor components, were not different, but the $Rg_1$, Re, and Rc ginsenoside contents between the 2-year and 3-year roots showed significant differences. $Rg_1$ and Rc increased significantly in the 1-year to 2-year roots, and Re increased significantly from the 3-year root age. Rd increased slightly until the 2-year age and decreased from the 3-year age. Based on the ginsenoside distributions and contents at various root ages, we have suggested 2 biogenesis schemes using the ginsenosides that have been isolated from the roots of P. ginseng so far.

Keywords

References

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