Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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The Alteration of Carbohydrate-Deficient Transferrin and Nerve Growth Factor in the Patients with Alcohol Dependence

알코올 의존 환자에서 탄수화물결핍 트랜스페린과 신경성장인자의 변화

  • Jeon, Chan-Min (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Park, Boung-Yang (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Byun, Jung-Hyun (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Lee, Boung-Chul (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Ham, Byung-Joo (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Hur, Mina (Department of Laboratory Medicine, College of Medicine, Hallym University) ;
  • Choi, Ihn-Geun (Department of Neuropsychiatry, College of Medicine, Hallym University)
  • 전찬민 (한림대학교 의과대학 신경정신과학교실) ;
  • 박병양 (한림대학교 의과대학 신경정신과학교실) ;
  • 변정현 (한림대학교 의과대학 신경정신과학교실) ;
  • 이병철 (한림대학교 의과대학 신경정신과학교실) ;
  • 함병주 (한림대학교 의과대학 신경정신과학교실) ;
  • 허미나 (한림대학교 의과대학 진단검사의학과학교실) ;
  • 최인근 (한림대학교 의과대학 신경정신과학교실)
  • Published : 2007.08.31
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Abstract

Objectives:Recent studies have raised the possibility that nerve growth factor(NGF) is abnormally regulated in the central nervous system(CNS) of animal models with alcohol dependence. The possible alteration of NGF by prolonged alcohol intake may play an important role in alcohol-induced neurotoxicity. Carbohydrate-deficient transferrin(CDT) is regarded as a reliable biological marker of alcohol dependence. The goal of this study was to estimate the changes of %CDT and serum NGF level according to the duration of alcohol abstinence, and to identify whether %CDT level is associated with the serum NGF level in the patients with alcohol dependence. Methods:The subjects were 24 patients with alcohol dependence. We used the Axis-Shield ASA to measure the %CDT level and the enzyme-linked immunosorbent assay(ELISA) to measure the serum NGF level. %CDT and NGF levels were measured immediately after the admission and at 2 weeks after the admission. Results:Decreased %CDT were observed during the period of 2 weeks after the admission. NGF level was not significantly different after 2 weeks. The NGF levels were not correlated with %CDT. The possibility of %CDT as a predictor of alcohol-induced neurotoxicity was not confirmed. Conclusion:Serum NGF levels is not a reliable indicator of abstinence state in the patients with alcohol dependence. Further studies are needed to evaluate the relation between two indicators in regard to hematological and neurological changes in alcohol dependence.

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