Incidental Multiple Pulmonary Nodules: Benign Metastasizing Leiomyoma and $^{18}F-FDG$ PET/CT

우연히 발견된 다발성 폐결절: 양성 전이성 근종과 $^{18}F-FDG$ PET/CT

  • Lee, Seok-Mo (Department of Nuclear Medicine, Kosin University Medical School)
  • 이석모 (고신대학교 의과대학 핵의학교실)
  • Published : 2007.06.30

Abstract

Benign metastasizing leiomyoma(BML) is a rare condition affecting women with a history of having undergone hysterectomy or myomectomy for a benign uterine fibroid, that is found to have metastasized to extrauterine sites, usually many years after hysterectomy. 1,2) Patient with BML almost always asymptomatic, although if the lesions are large enough, they can cause compressive symptoms. Among several hypothesis of pathogenesis, most plausible theory is that these tumors represent a true metastatic lesion but are very low-grade sarcoma. 3) Because the tumor is responsive to estrogen, menopause and pregnancy have slowed the growth of these lesion 4) and it seems reasonable to perform hysterectomy in patients with a uterine mass and, at the same time, perform oophorectomy for hormonal control. BML is an unusual cause of diffuse pulmonary nodules which should be considered in females with unexplained nodules and a history of surgery for uterine leiomyoma.

Keywords

References

  1. Arif S, Ganesan R, Spooner D. Intravascular leiomyomatosis and benign metastasizing leiomyoma: an unusual case. Int J Gynecol Cancer 2006;16:1448-50 https://doi.org/10.1111/j.1525-1438.2006.00607.x
  2. Mark S.A. Multiple benign lung tumors. Semin Thorac Cardiovasc Surg 2003;15(3):310-4 https://doi.org/10.1016/S1043-0679(03)70012-4
  3. Tietze L, Gunther K, Horbe A, Pawlik C, Klosterhalfen B, Handt S, Merkelbach-Bruse S. Benign metastasizing leiomyoma: a cytogenetically blanced but clonal disease. Hum Pathol 2006;31: 126-8 https://doi.org/10.1016/S0046-8177(00)80210-5
  4. Horstmann JP, Pietra GG, Harman JA, Cole NG, Grinspan S. Spontaneous regression of pulmonary leiomyomas during pregnancy. Cancer 1977;39(1):314-21 https://doi.org/10.1002/1097-0142(197701)39:1<314::AID-CNCR2820390148>3.0.CO;2-N