한국환경과학회지 (Journal of Environmental Science International)

  • 제16권8호
  • /
  • Pages.995-999
  • /
  • 2007
  • /
  • 1225-4517(pISSN)
  • /
  • 2287-3503(eISSN)
한국환경과학회 (The Korean Environmental Sciences Society)
권호 표지
DOI QR코드

DOI QR Code

김해시 공업지역의 대기 중 Methylethylketone 측정과 활성산소종 생성에 관한 연구

Detection of Methylethylketone in the Ambient Air of Industrial Area in Gimhae City and Its Effect on the Generation of Reactive Oxygen Species

  • 박흥재 (인제대학교 환경공학부/생명환경연구소) ;
  • 정성욱 (인제대학교 환경공학부/생명환경연구소) ;
  • 김종명 (부경대학교 양식학과) ;
  • 안원근 (부산 대학교 나노메디컬 공학과)
  • Park, Heung-Jai (School of Environmental Science and Engineering/Bio- Environmental Institute, Inje University) ;
  • Jeong, Seong-Wook (School of Environmental Science and Engineering/Bio- Environmental Institute, Inje University) ;
  • Kim, Jong-Myoung (Department of Aquaculture, Pukyong National University) ;
  • An, Won-Gun (Department of Nanomedical Engineering, Pusan National University)
  • 발행 : 2007.08.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study assessed the characteristics of emission and cell toxicology of Methylethylketone(MEK) in ambient air of industrial area. MEK is produced by the oxidation of sec-butyl alcohol and used as the solvent for making ink, printing, coating of film, bonding material and drug extraction. The MEK concentrations in the ambient-air of industrial area in Gimhae City was detected in the range of $25.4{\sim}1,580{\mu}g/m^3$ with an average $297.4{\mu}g/m^3$. The concentration of MEK showed a descending tendency from April to August followed by its increased tendency since then. The effects of MEK on the human lung cancer A549 cells was examined by the generation of Reactive Oxygen Species(ROS) and cytotoxicity. The range of MEK concentration detected in the area induced ROS generation affecting the oxidation state with a little effects on the viability of the cells.

키워드

참고문헌

  1. 봉상훈, 2007, 김해지역 대기중 휘발성유기화합물 특성연구-김해시 동지역을 중심으로-, 석사학위논문, 환경공학부, 인제대학교, 김해
  2. 나광삼, 김용표, 문길주, 1999, 울산공단 대기에서 측정한 휘발성 유기화합물의 1997년과 1998년 결과비교, 한국대기환경학회지, 15(5), 567-574
  3. 김용표, 이종훈, 진현철, 문길주, 1997, 여천공단 대기중의 입자상 및 기체상 이온성분과 유기화합물의 농도, 한국대기보전학회지, 13(4), 267-277
  4. Le B. M., Clement M. V., Pervaiz S., Brenner C., 2005, Reactive oxygen species and the mitochondrial signaling pathway of cell death, Histol. Histopathol., 20, 205-19
  5. Chen Q., Fischer A., Reagan J. D., Yan L. J., Ames B. N., 1995, Oxidative DNA damage and senescence of human diploid fibroblast cells, Proc. Natl. Acad. Sci. U S A., 92, 4337-4341
  6. Moldovan L., Moldovan N. I., 2004, Oxygen free radicals and redox biology of organelles, Histochem. Cell Biol., 122, 395-412 https://doi.org/10.1007/s00418-004-0676-y
  7. Frossi B., Tell G., Spessotto P., Colombatti A., Vitale G., Pucillo C., 2002, $H_{2}O_{2}$ induces translocation of APE/Ref-1 to mitochondria in the Raji-cell line, J. Cell Physiol., 193, 180-186 https://doi.org/10.1002/jcp.10159
  8. Nohl H., Jordan W., 1980, The metabolic fate of mitochondrial hydrogen peroxide, Eur. J. Biochem., 111, 203-210 https://doi.org/10.1111/j.1432-1033.1980.tb06094.x
  9. Mirza S., Miroshnyk I., Heinamaki J., Christiansen L., Karjalainen M., Yliruusi J., 2003, Influence of solvents on the variety of crystalline forms of erythromycin, AAPS. PharmSci., 5(2), E12
  10. Gius D., Spitz D. R., 2006, Redox signaling in cancer biology, Antioxid. Redox Signal., 8, 1249-1252 https://doi.org/10.1089/ars.2006.8.1249