Journal of Microbiology and Biotechnology

  • 제17권7호
  • /
  • Pages.1217-1220
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  • 2007
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Antifungal Cyclopeptolide from Fungal Saprophytic Antagonist Ulocladium atrum

  • Yun, Bong-Sik (Functional Metabolomics Research Center, KRIBB) ;
  • Kwon, Eun-Mi (Department of Applied Biology, Chungnam National University) ;
  • Kim, Jin-Cheol (Biological Function Research Team, KRICT) ;
  • Yu, Seung-Hun (Department of Applied Biology, Chungnam National University)
  • 발행 : 2007.07.31
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초록

The saprophytic fungus Ulocladium atrum Preuss is a promising biological control agent for Botrytis cinerea in greenhouse- and field-grown crops. However, despite its known potent antifungal activity, no antifungal substance has yet been reported. In an effort to characterize the antifungal substance from U. atrum, we isolated an antibiotic peptide. Based on extensive spectroscopic analyses, its structure was established as a cyclopeptolide with a high portion of N-methylated amino acids, and its $^1H$ and $^{13}C$ chemical shifts were completely assigned based on extensive 1D and 2D NMR experiments. Compound 1 exhibited potent antifungal activity against the plant pathogenic fungus Botrytis cinerea and moderate activity against Alternaria alternate and Magnaporthe grisea.

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참고문헌

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