Gefitinib-Related Interstitial Pneumonia

Gefitinib 투여 후 발생한 간질성 폐렴

  • Lee, Ho Jin (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Nam, Seung Bum (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Jung, Jae Wook (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Na, Im Il (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Kim, Cheol Hyeon (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Ryoo, Baek-Yeol (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Choe, Du Whan (Department of Radiology, Korea Cancer Center Hospital) ;
  • Kang, Jin Hyung (Department of Internal Medicine, Kangnam St. Mary's Hospital) ;
  • Lee, Jae Cheol (Department of Internal Medicine, Korea Cancer Center Hospital)
  • Received : 2007.01.23
  • Accepted : 2007.02.22
  • Published : 2007.02.28

Abstract

Gefitinib is a novel drug used to treat advanced non-small cell lung cancer. However, drug-related interstitial pneumonia is a major life-threatening side effect, which has a worldwide prevalence of 0.3-0.4%. In Japan, the prevalence is high as 3-4% but the actual frequency in Korea has not been officially assessed. We report two cases of gefitinib-induced interstitial lung disease during the treatment of non-small cell lung cancer. High-resolution computerized tomography (HRCT) of one case showed nonspecific ground glass opacity and the chest x-ray of another case showed diffuse bilateral ground glass opacity. The former patient showed a rapid good response to corticosteroid treatment whereas the latter died despite receiving aggressive treatment with high dose corticosteroid and empirical antibiotics.

Gefitinib은 진행성 비소세포성 폐암에 사용이 증가되고 있는 새로운 표적 항암 치료제로써 대부분이 경미한 부작용을 보이나 심각한 약제 유발성 간질성 폐렴이 발생 할 수 있다. 발생 빈도가 높은 일본에서는 유병률이 3.5%까지도 보고 된 바 있으나 현재 우리나라에서는 EAP에서 확인된 1건을 제외하고는 보고가 거의 없어 gefitinib로 인한 간질성 폐렴에 대한 낮은 인지도와 감별 진단의 어려움 등이 문제가 되는 것으로 판단된다. 저자들은 gefitinib에 의한 간질성 폐렴 2례를 경험하였기에 이를 보고하는 바이다.

Keywords

References

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