2 Cases of Mycoplasma pneumoniae Infection with Severe Pneumonia

중증 폐렴의 임상상을 보인 마이코플라즈마 감염 2예

  • Kim, Shin-Tae (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Shun Nyung (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Seok Jeong (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Jung, Pil Moon (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Park, Hong Jun (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Shin, Myung Sang (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Chong Whan (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Bu Ghil (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Sang-Ha (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Won-Yeon (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Shin, Kye Chul (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Yong, Suk Joong (Department of Internal Medicine, Yonsei University Wonju College of Medicine)
  • 김신태 (연세대학교 원주의과대학 내과학교실) ;
  • 이선녕 (연세대학교 원주의과대학 내과학교실) ;
  • 이석정 (연세대학교 원주의과대학 내과학교실) ;
  • 정필문 (연세대학교 원주의과대학 내과학교실) ;
  • 박홍준 (연세대학교 원주의과대학 내과학교실) ;
  • 신명상 (연세대학교 원주의과대학 내과학교실) ;
  • 김종환 (연세대학교 원주의과대학 내과학교실) ;
  • 이부길 (연세대학교 원주의과대학 내과학교실) ;
  • 김상하 (연세대학교 원주의과대학 내과학교실) ;
  • 리원연 (연세대학교 원주의과대학 내과학교실) ;
  • 신계철 (연세대학교 원주의과대학 내과학교실) ;
  • 용석중 (연세대학교 원주의과대학 내과학교실)
  • Received : 2007.10.12
  • Accepted : 2007.11.06
  • Published : 2007.12.30

Abstract

Mycoplasma pneumoniae (M. pneumoniae) is the leading cause of pneumonia in older children and young adults. Normally, it does not progress to a condition requiring hospitalization but improves spontaneously or has a mild clinical course. We report two cases of M. pneumoniae pneumonia with different clinical manifestations from the normal course. The patients were young healthy individuals. The diagnoses were made by serology. However, it could not be determined beforehand that they had M. pneumoniae pneumonia. Based on the empirical treatment strategy of severe community acquired pneumonia, the patients were treated with broad-spectrum antibiotics including cephalosporin, quinolone and macrolide. After administering the antibiotics, they showed a gradually favorable clinical course and recovered without residual complications. A M. pneumoniae infection should be considered as a cause of severe community acquired pneumonia, and empirical treatment targeting this organism might be helpful in treating patients with the severe manifestation.

M. pneumoniae는 지역사회폐렴의 중요한 원인균으로 대개 경증의 임상상을 보이지만 급성호흡곤란증후군을 일으킬 정도로 중증의 폐렴을 보이는 경우가 드물게 보고 되고 있다. 저자들은 일반적인 임상적인 경과와 달리 심한 폐침윤과 호흡곤란을 호소한 M. pneumoniae 폐렴 2예를 보고한다. 이들은 M. pneumoniae 폐렴의 전형적인 임상양상을 보이지 않았으나 중증지역사회폐렴의 양상을 보여 처음부터 새로운 퀴놀론이나 마크로라이드가 포함된 경험적 항생제 투여를 시작하였다. 또한 처음부터 M. pneumoniae IgG또는 IgM의 의미있는 상승과 추적검사에서 더욱 상승된 항체가를 보이고 혈청 검사에서 다른 감염증의 가능성을 배제하여 M. pneumoniae 폐렴으로 진단하였으며 합병증을 남기지 않고 치료가 되었다. 두 증례를 통하여 저자들은 M. pneumoniae 감염이 중증의 지역사회폐렴의 원인의 하나로 고려되어야 하며, 중증 폐렴소견을 보이는 경우에도 마크로라이드나 퀴놀론을 포함한 경험적 항생제 치료가 필요할 수 있음을 경험하여 보고한다.

Keywords

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