Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidative Activities of Phenolic Compounds Isolated from Inonotus obliquus

차가버섯으로부터 분리한 페놀성 화합물의 항산화효과

  • Kim, Hyoung-Ja (Bioanalysis and Biotransformation Research Center, Division of Life Sciences, Korea Institute of Science & Technology, Kyung Hee East-West Pharmaceutical Research Institute, Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University) ;
  • Jin, Chang-Bae (Bioanalysis and Biotransformation Research Center, Division of Life Sciences, Korea Institute of Science & Technology, College of Pharmacy, Kyung Hee University) ;
  • Lee, Yong-Sup (Kyung Hee East-West Pharmaceutical Research Institute, Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University)
  • 김형자 (한국과학기술연구원 생체대사연구센터, 경희대학교 약학대학) ;
  • 진창배 (한국과학기술연구원 생체대사연구센터) ;
  • 이용섭 (경희대학교 약학대학)
  • Published : 2007.06.30
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Abstract

ln our continued search for biologically active compounds from traditional medicine, we found that ethyl acetate fraction from Inonotus obliquus showed potent antioxidant activities on three different cell-free bioassay systems. Bioassay-directed chromatographic fractionation of the ethyl acetate fraction from Inonotus obliquus afforded four phenolic compounds, 4-(3,4-dihydroxyphenyl)-(E)-3-buten-2-one (1) , 3,4-dihydroxybenzaldehyde (2), protocatechuic acid (3) and caffeic acid (4) along with three sterols such as lanosterol (5), ergosterol peroxide (6) and 9,11-dehydroergosterol peroxide (7). Among isolates, phenolic compounds (1-4) were assessed for antioxidant activities. Almost phenolic compounds showed potent DPPH and superoxide anion radicals scavenging and lipid peroxidation inhibitory activities indicating that these phenolic compounds contribute to the antioxidative activities of I. obliquus. Compounds 2-3 and 7 were isolated for the first time from this plant.

Keywords

References

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