YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Relationship Between Histamine Release and Ca$^{2+}$ Mobilizaton in RBL 2H3 Mast Cells

RBL 2H3 비만세포에서 히스타민 유리와 칼슘과의 관계

  • Park, Sung-Hun (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Kim, Soo-Jeong (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Kim, Jung-Min (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Park, Ju-Hyun (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Choi, Bang-Shil (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Lee, Ji-Yun (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Choi, Mi-Yeong (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Sim, Sang-Soo (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
  • Published : 2007.02.28
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Abstract

To investigate the relation between extracellular Ca$^{2+}$ and histamine release, we observed agonist-induced histamine release from RBL 2H3 mast cells in the presence or absence of extracellular Ca$^{2+}$ concentration. Histamine release induced by melittin and thapsigargin were greater in the presence of extracellular Ca$^{2+}$ than in the absence of extracellular Ca$^{2+}$. Econazole-induced histamine release had nothing to do with extracellular Ca$^{2+}$, whereas arachidonic acid-induced histamine release increased in the absence of extracellular Ca$^{2+}$. Calmodulin antagonists did not affect melittin-induced histamine release but they may potentiate arachidonic acid-induced histamine release. These data suggest that arachidonic acid-induced histamine release may be mediated via Ca$^{2+}$-independent pathway and may be potentiated by the block of Ca$^{2+}$-dependent pathway.

Keywords

References

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