YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antifibrotic Effects of Oriental Herbs Extraction on Liver Cirrhosis

한약재(자하거, 백출, 차전자) 추출물의 간경화 억제효능에 관한 연구

  • 유병수 (원광대학교 자연과학대학 생명나노화학부) ;
  • 이종형 (원광대학교 자연과학대학 생명나노화학부) ;
  • 조성은 (원광대학교 자연과학대학 생명나노화학부) ;
  • 백승화 (원광대학교 한의학전문대학원)
  • Published : 2007.02.28
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Abstract

Hepatic cirrhosis is an important feature of chronic liver disease. Liver cirrhosis is characterized by hyperaccumulation of fibrous tissue components and is commonly observed in latter or terminal states of chronic hepatic disease. The antifibrotic effects on liver cirrhosis by oriental herbs extraction material were examined in bile duct ligated rats. Oriental herbs extraction (0.99 mg/kg rat weight/day) was administrated to cirrohotic rats for 4 weeks. Liver collagen content of bile duct ligated rats was significantly increased. And liver histology showed collagen fiber deposition was increased as well as the normal architecture was lost with large zone of necrosis being observed. Herbs extraction administrated rats showed significantly decreased liver collagen content, accumulation of collagen fiber in histological analysis, and biochemical markers of hepatic diseases. Those results demonstrate the usefulness of herbs extraction materials as an antifibrotic agent for liver cirrhosis.

Keywords

References

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