Effect of Aralia contientalis water-extracts on the Level of Cholesterol Accumulation in Rat, which were Treated with High-cholesterol Diet

Aralia contientalis가 고콜레스테롤 식이로 유발된 흰쥐 동맥경화에 미치는 영향

  • Shin, Sung-Ahn (Department of Diagnostics and Cardiovascular Medical Research Center, College of Korea Medicne, Dongguk University) ;
  • Park, Sun-Dong (Department of Prescription and Cardiovascular Medical Research Center, College of Korea Medicne, Dongguk University) ;
  • Choi, Dall-Young (Department of Pathology, College of Korean Medicne, Dongguk University) ;
  • Park, Won-Hwan (Department of Diagnostics and Cardiovascular Medical Research Center, College of Korea Medicne, Dongguk University)
  • 신승안 (동국대학교 한의과대학 심혈관계질환 천연물개발연구센터 및 진단학교실) ;
  • 박선동 (동국대학교 한의과대학 심혈관계질환 천연물개발연구센터 및 방제학교실) ;
  • 최달영 (동국대학교 한의과대학 병리학교실) ;
  • 박원환 (동국대학교 한의과대학 심혈관계질환 천연물개발연구센터 및 진단학교실)
  • Published : 2007.02.25

Abstract

Aralia contientalis show several beneficial effects including anti-oxidant effects. Aralia contientalis is used as a therapeutic agent to stop haemorrhages and a tonic to promoted health in Korean and Chinese medicine. The pharmacokinetic profiles of the main Aralia contientalis is still not accurately investigated. In present study, I examined the effects of water extracts of Aralia contientalis on high cholesterol diet atherosclerosis-induced rats in serum and abdominal aorta. A total of 3-week old 9 male rats of Sprague-Dawley were divided into 3 groups and fed with the basal diet (normal group), high cholesterol diet (atherosclerosis induced group) for 8 weeks, high cholesterol diet supplemented with water extracts of Aralia contientalis (Aralia contientalis group) for 2 weeks. And rats were sacrificed, serum lipid level, abodominal aortic anti-oxidant activities and lipid peroxide were measured. These results indicated that serum total cholesterl, LDL-cholesterol, triglycerides concentration significently lowered in Aralia contientalis group than high cholesterol diet group. But HDL-cholesterol concentraion significently higher in Aralia contientalis group than high cholesterol diet group.

Keywords

References

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