동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제21권2호
  • /
  • Pages.504-510
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  • 2007
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

가미천마구등음이 고혈압 병태모델에 미치는 영향

Effect of Kamicheonmagudeungeum on Hypertension

  • 송병용 (동신대학교 한의과대학 내과학교실) ;
  • 홍석 (동신대학교 한의과대학 내과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 전상윤 (동신대학교 한의과대학 내과학교실)
  • Song, Byoung-Yong (Department of Internal medicine, College of Oriental Medicine, Dongshin University) ;
  • Hong, Suk (Department of Internal medicine, College of Oriental Medicine, Dongshin University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Jeon, Sang-Yun (Department of Internal medicine, College of Oriental Medicine, Dongshin University)
  • 발행 : 2007.04.25
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초록

Kamicheonmagudeungeum(KCGE), a traditional herbal medicine, has been used as a therapeutic agent for the treatments of acute stage of hypertension. We evaluated the effects of KCGE on hypertension induced by DOCA-salt in rats. The systolic blood pressure and pulse rate significantly lowered by oral administration with KCGE. The levels of plasma hormones including dopamine, epinephrine and norepinephrine, and serum electrolyte were also reduced in KCGE treated rats. In addition, the production of reactive oxigen species (ROS) were greatly decreased by the treatment with KCGE in cultured bovine endothelial cells and angiotensine converting enzyme (ACE) activites were also inhibited by KCGE in a dose dependent manner. This study indicated that KCGE is a safe and effective treatment for hypertension.

키워드

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