Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study no the Antidiabetic Effect of Amomum xanthioides Extract

사인의 항당뇨 작용에 관한 연구

  • Lee, Ji-Hyun (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research) ;
  • Zhao, Zheng-Lim (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research) ;
  • Cho, Nam-Pyo (Department of Pathology, School of Dentistry, Chonbuk national University) ;
  • Park, Byung-Hyun (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research) ;
  • Kwon, Kang-Beom (Department of Physiology, School of Oriental Medicine, Wonkwang University) ;
  • Rho, Hye-Won (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research)
  • 이지현 (전북대학교 이과대학 생화학교실, 전북대학교 심혈관 연구소) ;
  • 조정임 (전북대학교 이과대학 생화학교실, 전북대학교 심혈관 연구소) ;
  • 조남표 (전북대학교 치과대학 병리학교실) ;
  • 박병현 (전북대학교 이과대학 생화학교실, 전북대학교 심혈관 연구소) ;
  • 권강범 (원광대학교 한의과대학 생리학교실) ;
  • 노혜원 (전북대학교 이과대학 생화학교실, 전북대학교 심혈관 연구소)
  • Published : 2007.04.25
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Abstract

The antidiabetic effect of Amomum xanthioides(A. xanthioides) extract was investigated. Alloxan caused the hyperglycemia and hypoinsulinemia by a selective destruction of pancreatic ${\beta}$-cell. Pretreatment of mouse with A. xanthiodies extract for 2 days prior to alloxan administration completely protected hyperglycemia induced by alloxan. In addition, administration of A. xanthioides extract to alloxan-induced diabetic mouse significantly abolished hyperglycemia, hypoinsulinemia, and, the reduction of size and number of insulin-secreting cells induced by alloxan. Administration of A. xanthioides extract to alloxan-induced diabetic mouse rapidly increased pancreatic Reg gene expression to 7 days, and then decreased. In alloxan-diabetic mouse. Reg gene expression was increased at 3 days after alloxan injection, and sustained until 24 days. The present results indicate that A. xanthioides extract contains potentially effective components exhibiting both protection and treatment of alloxan-induced diabetes. These results suggested that the antidiabetic effect of A. xanthoides extract may be mediated through the regeneration of pancreatic ${\beta}$-cells.

Keywords

References

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