동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제21권2호
  • /
  • Pages.408-413
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  • 2007
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

장미근(薔薇根) 메탄올 추출물의 혈관이완 기전에 대한 연구

Study on the Mechanism of Vascular Relaxation of Methanol Extract of Rose multiflora Radix

  • 김대중 (원광대학교 한의학전문대학원) ;
  • 조남근 (원광대학교 한의학전문대학원) ;
  • 이준경 (원광대학교 한의학전문대학원) ;
  • 조려화 (원광대학교 한의학전문대학원) ;
  • 이혁 (원광대학교 한의학전문대학원) ;
  • 안준석 (원광대학교 한의학전문대학원) ;
  • 엄재연 (원광대학교 한의과대학 한의학과) ;
  • 조규원 (원광대학교 한의과대학 한의학과) ;
  • 나한일 (원광대학교 한의과대학 한의학과) ;
  • 경은호 (원광대학교 한의과대학 한의학과) ;
  • 강대길 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의학전문대학원)
  • Kim, Dae-Joong (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jo, Nam-Geun (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jun-Kyoung (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Cao, Li-Hua (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Hyuck (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • An, Jung-Seok (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Um, Jae-Yeon (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Joe, Gye-One (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Na, Han-Il (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kyung, Eun-Ho (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gil (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 발행 : 2007.04.25
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초록

Vascular tone plays an important role in the regulation of blood pressure. In the present study, the methanol extract of Rosae multiflora Radix (MRM) induced dose-dependent relaxation of phenylephrine-precontracted aorta, which was abolished by removal of functional endothelium. Pretreatment of the endothelium-intact aortic tissues with $N^G$-nitro-L-arginine methly ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-${\alpha}$]-quinoxalin-1-one (ODQ) inhibited the relaxation induced by MRM, respectively. But, the relaxation effect of MRM was not blocked by indomethacine, glibenclamide, tetraethylammonium (TEA), verapamil, diltiazem, atropine, and propranolol, respectively. Moreover, incubation of endothelium-intact aortic rings with MRM increased the production of cGMP. Taken together, the present results suggest that MRM relaxes vascular smooth muscle via endothelium-dependent nitric oxide/cGMP signaling. These results would be useful for further study to MRM on animal models with cardiovascular diseases.

키워드

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