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Study on the Mechanism of Vascular Relaxation of Methanol Extract of Rose multiflora Radix  

Kim, Dae-Joong (Professional Graduate School of Oriental Medicine, Wonkwang University)
Jo, Nam-Geun (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Jun-Kyoung (Professional Graduate School of Oriental Medicine, Wonkwang University)
Cao, Li-Hua (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Hyuck (Professional Graduate School of Oriental Medicine, Wonkwang University)
An, Jung-Seok (Professional Graduate School of Oriental Medicine, Wonkwang University)
Um, Jae-Yeon (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University)
Joe, Gye-One (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University)
Na, Han-Il (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University)
Kyung, Eun-Ho (Department of Oriental Medicine, College of Oriental Medicine, Wonkwang University)
Kang, Dae-Gil (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.2, 2007 , pp. 408-413 More about this Journal
Abstract
Vascular tone plays an important role in the regulation of blood pressure. In the present study, the methanol extract of Rosae multiflora Radix (MRM) induced dose-dependent relaxation of phenylephrine-precontracted aorta, which was abolished by removal of functional endothelium. Pretreatment of the endothelium-intact aortic tissues with $N^G$-nitro-L-arginine methly ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-${\alpha}$]-quinoxalin-1-one (ODQ) inhibited the relaxation induced by MRM, respectively. But, the relaxation effect of MRM was not blocked by indomethacine, glibenclamide, tetraethylammonium (TEA), verapamil, diltiazem, atropine, and propranolol, respectively. Moreover, incubation of endothelium-intact aortic rings with MRM increased the production of cGMP. Taken together, the present results suggest that MRM relaxes vascular smooth muscle via endothelium-dependent nitric oxide/cGMP signaling. These results would be useful for further study to MRM on animal models with cardiovascular diseases.
Keywords
methanol extract of Rosae multiflor Radix(MRM); aortic tissues; endothelium; nitric oxide/cGMP; relaxation;
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