Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Suppression of DNCB-induced Dermatitis in NC/Nga Murine Model by Yanghyulyoonbu-tang

NC/Nga 아토피 피부염 생쥐 모델에서의 양혈윤부탕(養血潤膚湯) 효과

  • 박병준 (대전대학교 한의과대학 병리학교실) ;
  • 최정준 (대전대학교 한의과대학 병리학교실) ;
  • 김수명 (대전대학교 한의과대학 해부학교실) ;
  • 이용구 (대전대학교 한의과대학 내과학교실)
  • Published : 2007.04.25
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Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by inflammatory cell infiltration in the skin. This study was performed to assess the therapeutic effects of YHYBT on the DNCB-induced dermatitis in NC/Nga mice, characterized by the onset of AD along with an increase the number of Th2 cells and dysregulation of inflammaroty mediators including cytokines and chemokines. YHYBT administration significantly reduced clinical dermatitis severity including pruritus, edema, eczematous and erythema. Histological findings indicated that the thickening of epidermis/dermis and dermal infiltration of inflammatory cells including mast cells were dramatically reduced. The suppression of dermatitis by YHYBT was accompanied by a decrease in the total number of immune cells in drained lymph node (DLN) and skin. Especially CD3+, CD4+ and CD3+CD69+ T cells in PBMC and DNL were greatly reduced. The level of IL-4 in CD3/CD28 activated splenocyte was downregulated, whereas that of IFN-'처리불가‘ was increased. Furthermore, the expression of eotaxin2 and CCR3 in skin were significanlty decreased. These data suggest that YHTBT may be effective therapeutic agents for the treatment of AD.

Keywords

References

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