대한의생명과학회지 (Biomedical Science Letters)
- 제13권2호
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- Pages.141-148
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
gyrA and gyrB Mutations in Quinolone-resistant Strains of Enterobacteriaceae Isolated from General Hospitals in Busan
- Kim, Yun-Tae (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
- Kim, Tae-Un (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
- 발행 : 2007.06.30
초록
We determined the sequences of the quinolone resistance-determining region (QRDR) of gyrA and gyrB for 21 clinical strains of Enterobacteriaceae resistant to ciprofloxacin, norfloxacin and levofloxacin. The clinical strains were isolated from the specimens of three general hospitals in Busan. In the present study, we found mutations in type II topoisomerase (DNA gyrase) genes for all strains. We confirmed that some genera of Enterobacteriaceae of clinical specimen exhibited decreased sensitivity to fluroquinolone due to changes in Ser-83
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