Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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The effects of novel biodegradable amorphous Calcium Phosphate on bone regeneration in rat calvarial defects

새롭게 개발된 비정질의 Calcium Phosphate가 백서두개골의 골재생에 미치는 영향

  • Choi, Jung-Yoo (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Chae, Gyung-Joon (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chang-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Lee, Yong-Keun (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Cho, Kyoo-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Chai, Joong-Kyu (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
  • 최정유 (연세대학교 치과대학 치주과학교실) ;
  • 채경준 (연세대학교 치과대학 치주과학교실) ;
  • 김창성 (연세대학교 치과대학 치주과학교실) ;
  • 이용근 (연세대학교 치과대학 치주과학교실, 구강과학연구소) ;
  • 조규성 (연세대학교 치과대학 치주과학교실) ;
  • 채중규 (연세대학교 치과대학 치주과학교실) ;
  • 김종관 (연세대학교 치과대학 치주과학교실) ;
  • 최성호 (연세대학교 치과대학 치주과학교실)
  • Published : 2007.12.31
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Abstract

Purpose: The purpose of this study was to evaluate the bone regeneration of novel biodegradable amorphous calcium phosphate. Materials and Method: An 8-mm, calvarial, critical-size osteotomy defect was created in each of 20 male Sprague-Dawley rats(weight $250{\sim}300g$). The animals were divided into two groups of 10 animals each and allowed to heal for 2 weeks(10 rats). The first group was the control group and the other group was the experimental group which received the novel biodegradable calcium phosphate. Results: The healing of the calvarium in the control group was uneventful. The histologic results showed little bone formation in the control group. The experimental group which received the novel biodegradable calcium phosphate showed a normal wound healing. There were a lot of new bone formation around the biomaterial in 2 weeks. The bone formation increased in 8 weeks when compared to 2 weeks and there was a significant bone increase as well(P<0.01). The nobel biodegradable calcium phosphate showed statistical significance when compared to the control group (P<0.05). The novel biodegradable calcium phosphate in 8 weeks showed a significant increase in bone formation when compared to 2 weeks $(40.4{\pm}1.6)$(%). The biodegradable calcium phosphate which is made from mixing calcium phosphate glass(CPG), NaCO and NaOH solution, is biocompatible, osteoconductive and has a high potency of bone formation. Conclusion: We can conclude that the novel biodegradable calcium phosphate can be used as an efficient bone graft material for its biodegradability and osteoconductivity.

Keywords

References

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