한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제36권5호
  • /
  • Pages.521-526
  • /
  • 2007
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  • 1226-3311(pISSN)
  • /
  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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벤조피렌을 투여한 생쥐의 간 조직에서의 홍삼분말의 항산화 효과

Antioxidant Effects of Red Ginseng Powder on Liver of Benzo(α)Pyrene-Treated Mice

  • 김현정 (계명대학교 전통미생물자원개발 및 산업화연구센터) ;
  • 이지원 (계명대학교 식품가공학과) ;
  • 지영주 (계명대학교 식품가공학과) ;
  • 유미희 (계명대학교 식품가공학과) ;
  • 박정현 (계명대학교 전통미생물자원개발 및 산업화연구센터) ;
  • 이기동 (대구신기술사업단 바이오산업지원센터) ;
  • 이인선 (계명대학교 전통미생물자원개발 및 산업화연구센터)
  • Kim, Hyun-Jeong (The Center for Traditional Microorganism Resources, Keimyung University) ;
  • Lee, Ji-Won (Dept. of Food and Technology, Keimyung University) ;
  • Ji, Young-Ju (Dept. of Food and Technology, Keimyung University) ;
  • Yu, Me-Hei (Dept. of Food and Technology, Keimyung University) ;
  • Park, Jung-Hyun (The Center for Traditional Microorganism Resources, Keimyung University) ;
  • Lee, Ki-Dong (Daegu Bio Industry Center, Daegu New Technology Agency) ;
  • Lee, In-Seon (The Center for Traditional Microorganism Resources, Keimyung University)
  • 발행 : 2007.05.30
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초록

홍삼분말이 $B(\alpha)P$의 투여에 의한 간 독성이 유발된 생쥐에서의 글루타치온 및 과산화지질 함량, 항산화효소 활성에 미치는 영향을 살펴보았다. $B(\alpha)P$ 투여에 의해 증가된 혈청내 ALT와 AST의 활성이 홍삼분말 전 처리군에서는 감소하였다. 간 조직중의 글루타치온 함량은 $B(\alpha)P$ 단독군에서는 감소되었다가 홍삼분말 투여시 유의적인 증가를 보였고, 지질과산화물 함량은 $B(\alpha)P$ 투여시 증가되었다가 홍삼분말의 투여시 유의적으로 감소되었다. 간 조직중의 SOD, catalase 그리고 GSH-Px의 활성도 $B(\alpha)P$ 투여로 유의적으로 증가되었다가, 홍삼분말의 투여로 이들 활성이 유의적으로 감소하였다. 반면, GST 활성은 $B(\alpha)P$ 단독군에서는 감소되었다가 홍삼분말 투여시 유의적인 증가를 보였다. 이상의 결과로 홍삼분말은 항산화효소의 활성에 의한 $B(\alpha)P$에 의한 간 손상에 대한 보호효과를 가지는 것으로 사료된다.

The effects of red ginseng powder on hepatotoxicity in $benzo(\alpha)pyrene\;[B(\alpha)P]$-treated mice were investigated. Male ICR mice were pretreated with red ginseng powder (50 or 100 mg/kg/day, for 5 days, intraperitoneally) before treatment with $B(\alpha)P$ (0.5 mg/kg, i.p, single dose). The ability of red ginseng powder to protect against oxidative damage to the mouse liver was examined by determining the level of lipid peroxide, glutathione, and the antioxidant enzyme activities. The glutathione content depleted by $B(\alpha)P$ were significantly increased by red ginseng powder, but elevation of lipid peroxide content induced by $B(\alpha)P$ was decreased by red ginseng powder. The increased activities of superoxide dismutase, catalase and glutathione peroxidase after $B(\alpha)P$-treatment were decreased by the treatment of red ginseng Powder; however, glutathione S-transferase activity depleted by $B(\alpha)P$ were significantly increased. These results suggest that red ginseng powder can protect against $B(\alpha)P$ intoxification through its antioxidant properties.

키워드

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