생약학회지 (Korean Journal of Pharmacognosy)

  • 제38권1호
  • /
  • Pages.62-66
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  • 2007
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

단삼 에탄올추출물이 유방암 예방 및 전이에 미치는 영향

Effect of Ethanol Extract from Salvia miltiorrhiza on Chemoprevention and Metastasis of Breast Cancer

  • 손윤희 (동국대학교 난치병한양방치료연구소) ;
  • 조현정 (동국대학교 난치병한양방치료연구소) ;
  • 김미경 (동국대학교 난치병한양방치료연구소) ;
  • 정은정 (동국대학교 의과대학 약리학교실) ;
  • 남경수 (동국대학교 의과대학 약리학교실)
  • Shon, Yun-Hee (Intractable Diseases Research Center, Dongguk University) ;
  • Cho, Hyun-Jung (Intractable Diseases Research Center, Dongguk University) ;
  • Kim, Mee-Kyung (Intractable Diseases Research Center, Dongguk University) ;
  • Jung, Eun-Jung (Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Nam, Kyung-Soo (Department of Pharmacology, College of Medicine, Dongguk University)
  • 발행 : 2007.03.31
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초록

Ethanol extract from Salvia miltiorrhiza (SME) was tested for breast cancer chemoprevention and metastasis by measuring the activites of cytochrome P45O 1A1, aromatase, ornithine decarboxylase (ODC), and matrix metalloproteinase (MMP)-9. SME significantly inhibited cytochrome P45O 1A1-mediated ethoxyresorufin O-deethylase (EROD) activity in a dose-dependent manner in a concentration range of 100${\sim}$l,200 ${\mu}g/ml$ (p<0.01). Microsomal aromatase (estrogen synthase) activity was suppressed 54.9%${\sim}$77.5% by the SME at concentration of 600${\sim}$l,200 ${\mu}g/ml$. ODC activity induced by 12-O-tet-radecanoylphorbol-13-acetate (TPA) was significantly reduced by the SME 900 and 1,200 ${\mu}g/ml$ (p<0.05) in MCF-7 breast cancer cells. In addition, SME (900 and 1,200 ${\mu}g/ml$) markedly inhibited MMP-9 activity, a key role in cancer metastasis. Therefore, SME is worth further investigation with respect to breast cancer chemoprevention or therapy.

키워드

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