KSBB Journal

  • 제22권4호
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  • Pages.265-269
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  • 2007
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  • 1225-7117(pISSN)
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  • 2288-8268(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
권호 표지

다시마 유래 Fucoidan의 In-vitro 포도당 및 담즙산 흡수지연 효과

In Vitro Glucose and Bile Acid Retardation Effect of Fucoidan from Laminaria japonica

  • 박갑용 (강원대학교 생물공학과) ;
  • 백진홍 (주) 김정문 알로에 생명과학연구소) ;
  • 허원 (강원대학교 생물공학과) ;
  • 이신영 (강원대학교 생물공학과)
  • Park, Kap-Yong (Department of Bioengineering and Technology, Kangwon National University) ;
  • Back, Jin-Hong (KJM Aloe R&D Center) ;
  • Hur, Won (Department of Bioengineering and Technology, Kangwon National University) ;
  • Lee, Shin-Young (Department of Bioengineering and Technology, Kangwon National University)
  • 발행 : 2007.08.30
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초록

다시마 fucoidan의 식이섬유로서의 생리기능성 탐색연구의 일환으로, 다시마의 건조 분말로부터 fucoidan을 열수 추출하여 분리하고 부분정제하였으며, 이의 in-vitro 포도당 및 담즙산 흡수 지연 효과를 조사하였다. 다시마 fucoidan은 투석막을 이용한 2시간 동안의 in-vitro glucose 및 bile acid 흡수 지연 실험에서 각각 25.36$\sim$22.68% 및 27.03$\sim$33.50%의 흡수지연효과를 나타내었다. 이들 효과는 타 식이섬유와 비교하여 비교적 우수하거나 매우 우수한 효과로, 어느 정도 당뇨 및 동맥경화 억제에의 효과를 나타낼 것이 기대되어 추가 검토의 필요성이 높았다.

Fucoidan from sea tangle (Laminaria japonica) was isolated by hot water extraction, and partially purified. The in-vitro glucose and bile acid retarding effects of the partially purified fucoidan were investigated. Fucoidan exhibited 27.06$\sim$21.42% of retarding index for glucose and 33.50$\sim$27.02% of retarding index for bile acid during in vitro dialysis experiment for 2 hours. These retarding effects on glucose and bile acid diffusion was considered as a relatively good or very good, suggesting the prevention from diabetes and arteriosclerosis of some extent.

키워드

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