KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Biochip System for Environmental Monitoring using Nanobio Technology

나노바이오기술을 이용한 환경모니터링용 바이오칩 시스템

  • Kim, Young-Kee (Department of Chemical Engineering, Hankyong National University) ;
  • Min, Jun-Hong (Department of Bionano Technology, Kyungwon University) ;
  • Oh, Byung-Keun (Department of Chemical and Biomolecular Engineering, Sogang University) ;
  • Choi, Jeong-Woo (Department of Chemical and Biomolecular Engineering, Sogang University)
  • 김영기 (한경대학교 화학공학과) ;
  • 민준홍 (경원대학교 바이오나노학과) ;
  • 오병근 (서강대학교 화공.생명공학과) ;
  • 최정우 (서강대학교 화공.생명공학과)
  • Published : 2007.12.31
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Abstract

Bio-sensing devices, which are basically integrated and miniaturized assay systems consisted of bioreceptor and signal transducer, are advantageous in several ways. In addition to their high sensitivity, selectivity, simplicity, multi-detection capability, and real time detection abilities, they are both very small and require relatively inexpensive equipments. Two core technologies are required to develop bio-sensing devices; the fabrication of biological receptor module (both of receptor development and immobilisation of them) and the development of signal transducing instruments containing signal generation technique. Various biological receptors, such as enzymes, DNA/RNA, protein, and cell were tried to develop bio-sensing devices. And, the signal transducing instruments have also been extensively studied, especially with regard to electrochemical, optical, and mass sensitive transducers. This article addresses bio-sensing devices that have been developed in the past few years, and also discusses possible future major trends in these devices.

바이오센싱 디바이스는 본질적으로 생체인식소재와 신호전달장치로 구성된 집적화, 소형화된 분석시스템으로 많은 장점을 가지고 있다. 고민감도, 선택도, 단순성, 다성분 측정능력, 즉시측정능력 뿐 아니라 매우 작고, 고가의 장치가 필요없는 장점이 있다. 바이오센싱 디바이스의 개발을 위해서는 두 가지의 핵심요소기술이 필요하다. 이것은 생체인식소재모듈의 제작 (리셉터 개발 및 고정화기법)과 신호발생기술을 포함한 신호전달장치의 개발이다. 효소, DNA/RNA, 단백질, 세포 등의 다양한 생체인식소재가 바이오센싱 디바이스 제작을 위해 이용되어져 왔고, 신호전달시스템도 전기화학적, 광학적, mass sensitive transducer를 중심으로 매우 활발히 연구되어져 왔다. 본 고에서는 최근 개발된 바이오센싱디바이스에 대해 다루고, 향후 전망에 대해 논하고자 한다.

Keywords

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