생명과학회지 (Journal of Life Science)

  • 제17권4호
  • /
  • Pages.575-580
  • /
  • 2007
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
DOI QR코드

DOI QR Code

오디 추출물이 갱년기 유도 흰쥐의 혈행 개선에 미치는 영향

The Effect of Mulberry Fruits Extracts on Blood Flow Improvement in Ovariectomized Rats

  • 발행 : 2007.04.25
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

여성의 폐경에 의한 estrogen의 감소는 심혈관계질환을 빠르게 진행시킨다고 알려져 있다. 최근 새로운 estrogen 대체 식물로 주목받고 있는 오디 추출물을 갱년기장애를 일으킨 흰쥐에 투여하여 혈액 유동성, 항 혈소판 응집능 및 혈 중 지질 수준 개선에 미치는 영향을 검토하였다. 오디 추출물 투여군의 경우 Ovx-control군보다 혈액 유동성이 빠르게 나타났고, 한국산 오디의 경우 sham군 정도의 혈액 유동성을 보였으며, 중국산의 경우는 sham군 보다 빠른 유동성을 나타내었다. 각 산지별 오디 추출물 투여군이 OVX-control군 보다 빠른 시간에 통과한 것으로 미루어 보아 오디가 혈액의 유동성에 좋은 영향을 줄 것으로 사료되어진다. 오디 추출물을 갱년기를 유도한 흰쥐에 투여하여 혈소판 응집 능에 미치는 영향을 검토한 결과 난소절제에 의하여 혈소판응집이 활성화 되었는데, 오디 추출물을 투여한 군에서 혈소판응집이 억제되는 것을 확인할 수 있었다. 또한, 난소 절제하여 갱년기 장애를 유도한 흰쥐에 각각의 오디 추출물을 투여하였을 때, total-cholesterol 및 혈 중 중성 지방이 낮아지고, HDL-cholesterol 함량이 높아지는 결과로 보아 국산 오디 추출물 뿐 아니라 타지키스탄, 중국산 오디 추출물 투여가 난소 절제에 의해 소실된 estrogen의 지질대사 불균형에 유익한 영향을 주어 관상동맥 질환 개선에 도움을 줄 것으로 사료된다.

The purpose of this study was to investigate the effect of three different mulberry cultivars extracts on inhibition of platelet aggregation and blood flow improvement. Four groups were surgically ovariectomized (OVX). The fifth group was sham operated. Sprague-Dawley strain female rats were randomly assigned to the following groups. sham-operated rats(Sham), ovariectomized control rats(OVX-Control), ovariectomized rats supplemented with 80% ethanol extracts from fruits of Tajikistan mulberry (OVX-TM), Korea mulberry (OVX-KM) and China mulbery (OVX-CM) at 200 mg/kg bw/d. The mulberry extracts were orally administrated at 1 ml per day. The body weights of OVX rats were significantly heavier than the sham-operated rats at all values (p<0.05). The serum triglyceride level was significantly decreased after supplemented with the CM and KM extracts. The serum HDL-cholesterol level in the OVX-KM group was significantly higher than that in the OVX-control group. The passage time of whole blood showed significant correlation with triglyceride but reverse correlation with HDL cholesterol. The ability of platelet aggregation of groups treated with mulberry extracts was less than OVX-control group. Taken these together, mulberry extracts may be used to possibly improve the quality of life in menopausal women.

키워드

참고문헌

  1. Abe, T., J. W. M. Chow, J. M. Lean and T. J. Chambers. 1993. Estrogen does not restore bone list after ovariectomy in the rat. J. Bone Miner. Res, 8, 831-838 https://doi.org/10.1002/jbmr.5650080709
  2. Aitken, J. M., E. Armstrong and J. B. Anderson. 1972. Osteroporosis after ophoretomy in the mature female rat and the effect of estrogen and ovariectomy or progesterone replacement therapy in its prevention. J. Endocrinol. 55, 79-87 https://doi.org/10.1677/joe.0.0550079
  3. Annual Report on the Cause of Death Statistics. National Statistical Office, Seoul, 1997
  4. Belchetz, P. E. 1994. Hormonal treatment of postmenopausal women. N. Eng. J. Med. 330, 1062-1071 https://doi.org/10.1056/NEJM199404143301508
  5. Brosage, P. 1995. Hormone therapy: The woman's decision. Contemp. Nurse Pract. 1 (S), 3
  6. Bush, T. L. and E. Barret-Connor. 1985. Noncontraceptive estrogen use and cardiovascular disease. Epidemiol. Rev. 7, 89-104
  7. Cecily, C. K. 1990. Clinical aspects of the relationship between oral contraceptives and abnormalities of the hemostatic system: Relation to the development of cardiovascular disease. Am. J. Obstet. Gynecol. 163, 392-395 https://doi.org/10.1016/0002-9378(90)90589-Y
  8. Cha, J. Y., H. J. Kim and Y. S. Cho. 2000. Effect of water-soluble extract from leaves of Morus alba and Cudrania tricuspidata on the lipid concentrations of serum and liver in rats. J. Korean Soc. Agric. Chem. Biotechnol. 43, 303-308
  9. Chen, F., N. Nakashima, J. Kimura and M. Kimura. 1995. Hypoglycemic activity and mechanisms of extracts from mulberry leaves(Folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice. Yakugaku Zasshi 15, 476-482
  10. Colditz, G. A., S. E. Hankinson, D. J. Hunter, W. C. Willett, J. E. Menson, M. J. Stampfer, C. Hennekens, B. Rosner and F. E. Speizer. 1995. The use of estrogens and progenstins and the risk of breast cancer in postmenopausal women. New. Engl. J. Med. 332, 1589-1593 https://doi.org/10.1056/NEJM199506153322401
  11. Cook, N. S., H. G. Zerowes, C. TapparelI, M. Pawling, J. Singh, R. Matternich and A. Hagenbach. 1993. Platelet aggregation and fibrinogen binding in human, rhesus minkey, guinea-pigs hamster and rat blood ; activation by ADP and a thrombin receptor peptide and inhibition by glycoprotein IIb/IIIa antagonist. Thrombosis and Haernostosis 70, 531-539
  12. Dodds W. J. 1978. Platelet function in animals: species specificities. In platelets : Multidisciplinary Approach, ed. G. De Gaetana and S. Garattini, pp. 45-49. Raven Press, New York
  13. Falk, E., P. K. Shah and V. Fuster. 1995. Coronary plaque disruption. Circulation 92, 657-671 https://doi.org/10.1161/01.CIR.92.3.657
  14. Grodstein, F., M. J. Stamfer, G. A. Colditz, W. C. Willett, J. E. Manson, M. Joffe, B. Rosner, C. Fuchs, S. E. Hankinson, D. J. Hunter, C. H. Hennekens and F. E. Speizer. 1997. Postmenopausal hormone therapy and mortality. New. Engl. J. Med. 336, 1769-1775 https://doi.org/10.1056/NEJM199706193362501
  15. Harris, R. B., A. Laws, F. M. Reddy, A. King and W. L. Haskell. 1990. Are women using postmenopausal estrogens? A community survey. Am. J. Public Health 80, 1266-1268 https://doi.org/10.2105/AJPH.80.10.1266
  16. Jeong, C. H., O. S. Joo and K. H. Shim. 2002. Chemical components and physiological activities of young mulberry(Morus alba) stem. Korean journal of Food Preservation 9, 228-233
  17. Kim, H. B., G. J. Bark, Y. S. Seok, S. L. Kim, G. B. Sung, H. W. Nam and J. Y. Moon. 2002. Morphological characteristics and physiological effects of mulberry leaves and fruits with wild varieties, Korean Scociety of Sericultural Science 44, 4-8
  18. Kim, H. B., S. Y. Kim, G. S. Rue, Y. J. Lee and J. Y. Moon. 2001. Effect of methanol extract from mulberry fruit on the lipid metabolism and liver function in cholesterol-induced hyperlipidemia rats, Korean Scociety of Sericultural Science 42, 104-108
  19. Kim, H. B, H. S. Bang, H. W. Lee, Y. S. Seuk and B. S. Gyoo. 1999. Chemical characteristics of mulberry syncarp. Korean J. Seric. Sci. 41, 123-128
  20. Kim, S. H., H. Y. Park and W. K. Park. 1988. Determination and physical properties of dietary fiber in seaweed products. J. Korean Soc, Food Sci. Nutr. 17, 320-325
  21. Kim, S. Y. and K. J. Park. 1998. Antiinflammatory and antioxidative effects of morus spp. fruit extract. Korean J. Medicinal Crop Sci. 6, 204-209
  22. Kim, S. Y, W. C. Lee, H. B. Kim, A. J. Kim and S. K. Kim. 1998. Antihyperlipidemica effects of methanol extracts from mulberry leaves in cholesterol-induced hyperlipidemia rats. J. Kor. Soc. Food Sci. Nurt. 27, 1217-1222
  23. Kim, T. W, Y. B. Kwon, Lee, J. H. Yang, I. S. Youm, J. K. Lee, H. S and J. Y. Moon. 1996. A study on the antidiabetic effect of mulberry fruits. Korean. J. Seric. Sci. 38, 100-107
  24. Meade, Y. W. 1982. Oral contraceptives, clotting factors, and thrombosis. Am. J. Obstet. Gynecol. 142, 758-761 https://doi.org/10.1016/S0002-9378(16)32484-X
  25. Nakamura, H., F. Kinoshita, K. Itou, K. Mugitani, H. Oohata, M. Iwane, A. Yoshikawa and O. Mohara. 2004. Analysis of factors which relate to lifestyle related diseases observed from blood rheology. JJCDP 39, 1-4
  26. Ramirez, M. E., M. P. McMurry, G. A. Wiebke, K. J. Felton and K. Ren, 1997. Evidence for sex steroid inhibition of lipoprotein lipase in men; comparison of abdominal and femoral adipose tissue. Metabolism 46, 179-185 https://doi.org/10.1016/S0026-0495(97)90299-7
  27. Ross, R. K., A. Pagamm-Hill, T. M. Mark and B. E. Henderson. 1989. Cardiovascular benefits of estrogen replacement therapy. Am. J. Obstet Gynecol. 160, 1301-1306 https://doi.org/10.1016/S0002-9378(89)80017-1
  28. Sabra, A. and J. Bonnar. 1983. Hemostatic system changes induced by $50{\mu}g$ and $30{\mu}g$ estrogen/progestogen oral contraceptives. Modification of estrogen effects by levonorgestrel. J. Reprod. Med. 28(1 suppl). 85-91
  29. Spiller, G. A. and R. J. Amen. 1975. Dietary fiber in human nutriation. Crit. Rev. Food Sci. Nutr. 7, 39-66 https://doi.org/10.1080/10408397509527201
  30. Stadel, B. V. 1981. Oral contraceptives and cardiovascular disease(1st of 2 parts). N. Eng. J. Med. 305, 612-616 https://doi.org/10.1056/NEJM198109103051104
  31. Stolley, P. D., J. A. Tonascia. M. S. 'I'ockman, P. E. Sartwell, A. H. Rutledge and M. P. Jacobs. 1975. Thrombosis with low-estrogen oral contraceptives. Am. J. Epidem. 102, 197-201 https://doi.org/10.1093/oxfordjournals.aje.a112148
  32. Valette, A., K. M. Meignen, L. Mercier, J. G. Liehr and J. Boyer. 1986. Effects of 2-fluoroestradiol on lipid metabolism in the ovariectomized rat. J. Steroid Biochem. 25, 575-578 https://doi.org/10.1016/0022-4731(86)90405-X
  33. Vessey, M. P. 1984. Oral contraceptives and stroke : Finding in a large prospective study. Br. Med. J. 289, 530-532
  34. Wickelgren, I. 1997. A new weapon against Alzheimer's. Science 276, 676-677 https://doi.org/10.1126/science.276.5313.676
  35. Wronski, T. J., M. Cintron and L. M. Dann. 1988. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif. Tissue. Int. 43, 179-183 https://doi.org/10.1007/BF02571317

피인용 문헌

  1. Effect of Omija (Schisandra chinensis Baillon) Addition Ratio on Quality Characteristics of Mulberry Extracts vol.44, pp.7, 2015, https://doi.org/10.3746/jkfn.2015.44.7.1041
  2. Quality characteristics and changes in mulberry (Morus alba L.) depending on their maturity during distribution vol.20, pp.3, 2013, https://doi.org/10.11002/kjfp.2013.20.3.304
  3. Changes in Quality of Mulberry Depending on Distribution and Storage Temperature vol.20, pp.2, 2013, https://doi.org/10.11002/kjfp.2013.20.2.141
  4. Effect of Mulberry (Morus alba L.) Extract on Blood Flow Improvement vol.43, pp.4, 2014, https://doi.org/10.3746/jkfn.2014.43.4.498
  5. Gagamyeonryunggobon-dan(Jiājiǎnyánlínggùběn-dān) induces hair regrowth effect from activating hair follicle vol.29, pp.1, 2016, https://doi.org/10.6114/jkood.2016.29.1.065
  6. Effects of dietary Mulberry Leaf Supplementation on the Performance, Egg Quality and Blood Composition for the Finishing Stage of Laying Hens vol.52, pp.2, 2018, https://doi.org/10.14397/jals.2018.52.2.81