Post-Infarction Ventricular Septal Rupture : 10 Years of Experience

급성 심근경색증 후 심실중격 결손: 10년 경험

  • Jung, Yo-Chun (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Cho, Kwang-Ree (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Kim, Ki-Bong (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine)
  • 정요천 (서울대학교 의과대학 서울대학교병원 흉부외과학교실) ;
  • 조광리 (서울대학교 의과대학 서울대학교병원 흉부외과학교실) ;
  • 김기봉 (서울대학교 의과대학 서울대학교병원 흉부외과학교실)
  • Published : 2007.05.05

Abstract

Background: Postinfarction ventricular septal rupture is associated with mortality as high as $85\sim90%$, if it is treated medically. This report documents our experience with postinfarction ventricular septal rupture that was treated surgically, Material and Method: We retrospectively reviewed the medical records of 11 patients who were operated on due to postinfarction ventricular septal rupture between August 1996 and August 2006. There were 4 men and 7 women, with a mean age of $70{\pm}11$ years (age range: $50\sim84$ years). The location of the rupture was anterior in 7 cases and posterior in 4 cases. The interval between the onset of acute myocardial infarction and the occurrence of the ventricular septal rupture was $2.0{\pm}1.3$ days (range: $1\sim5$ days). Operation was performed at an average of $2.4{\pm}2.7$ days (range: $0\sim8$ days) after the diagnosis of septal rupture. Preoperative intraaortic balloon pump therapy was performed in 10 patients. Result: The infarct exclusion technique was used in all cases. Coronary artery bypass grafting was done in 8 cases, with the mean number of distal anastomosis being $1.0{\pm}0.8$. There was one operative death. In 2 patients, reoperation was performed due to a residual septal defect. The postoperative morbidities were transient atrial fibrillation (n=7), paroxysmal supraventricular tachycardia (n=1), low cardiac output syndrome (n=3), bleeding reoperation (n=2), delayed sternal closure (n=2), acute renal failure (n=2), pneumonia (n=1), intraaortic balloon pump-related thromboembolism (n=1), and transient delirium (n=2). Nine patients have been followed up for a mean of $38{\pm}40$ months except for one follow-up loss. There have been 3 late deaths. At the latest follow-up, all 6 survivors were in a good functional class. Conclusion: We demonstrated satisfactory operative and midterm results with our strategy of preoperative intraaortic balloon pump therapy, early repair of septal rupture by infarct exclusion and combined coronary revascularization.

배경: 급성 심근경색증에 합병된 심실중격 결손은 내과적 치료만으로는 $85\sim90%$의 높은 사망률을 보이는 질환으로서, 본 병원에서의 외과적 치료 경험을 분석하였다. 대상 및 방법: 1996년 8월부터 2006년 8월 사이에 급성 심근경색증 후 합병된 심실중격 결손으로 수술적 치료를 시행한 11예를 대상으로 후향적으로 의무기록을 검토하였다. 남자가 4명, 여자가 7명이었으며 평균연령은 $70{\pm}11$ (범위, $50\sim84$)세였다. 심실중격 결손의 위치는 전중격 결손이 7예, 후중격 결손이 4예 있었다. 심실중격 결손은 급성 심근경색 후 $2.0{\pm}1.3$ (범위, $1\sim5$)일째에 발견되었으며 심실중격 결손의 진단 후 $2.4{\pm}2.7$ (범위, $0\sim8$)일째에 수술을 시행하였다. 모든 환자에서 수술전 심초음파와 관상동맥조영술을 시행하여 심실중격 결손의 위치, 심실 기능, 그리고 관상동맥 병변을 파악하였으며, 수술 전에 대동맥내 풍선 펌프를 삽입한 경우가 10예 있었다. 결과: 11예 모두에서 infarct exclusion 술식을 시행하였고, 8예에서는 관상동맥우회술을 함께 시행하였으며 평균 문합수는 $1.0{\pm}0.8$개였다. 수술 사망은 1예였으며 수술 후 초음파 소견에서 잔여 단락이 발견되었던 2예에서는 첩포의 누출에 대해 재수술을 시행하였다. 그 밖의 합병증으로는 일시적인 심방세동(7예), 발작성 심실상성빈맥(1예), 저심박출증(3예), 재수술이 필요했던 출혈(2예), 흉골 지연봉합(2예), 급성 신부전(2예), 폐렴(1예), 대동맥내 풍선펌프로 인한 혈전색전증(1예),수술 후 섬망(2예) 등이 있었다. 생존한 10명의 환자들 중 1명을 제외한 나머지 9명의 환자에서 $38{\pm}40$개월간의 추적관찰이 되었는데, 추적 관찰 기간 중에 3명이 사망하였고 생존한 6명의 환자는 모두 양호한 상태(NYHA 기능등급, $I{\sim}II$)를 보였으며, 그 중 3명에서는 혈역학적으로 큰 의미가 없는 잔여단락이 있었다. 결론: 급성 심근경색증 후 심실중격 결손은 수술위험도가 높은 질환이지만, 수술 전 대동맥내 풍선펌프를 삽입하고 조기에 심실중격 결손부의 infarct exclusion 술식과 함께 관상동맥우회술을 시행함으로써 만족할 만한 수술 및 중기 결과를 얻을 수 있었다.

Keywords

References

  1. Sanders RJ, Kern WH, Blount SG. Perforation of the interventricular septum complicating myocardial infarction. Am Heart J 1956;51:736-48 https://doi.org/10.1016/S0002-8703(56)80008-2
  2. Cooley DA, Belmonte BA, Zeis LB, Schmir S. Surgical repair of ruptured interventricular septum following acute myocardial infarction. Surgery 1957;41:930-7
  3. Deville C, Fontan f, Chevalier JM, Madonna F, Ebner A, Basse P. Surgery of postinfarction ventricular septal defect: risk factors for hospital death and long-term results. Eur J cardiothorac Surg 1991;5:167-75 https://doi.org/10.1016/1010-7940(91)90026-G
  4. Moore CA, Nygaard TW, Kaiser DL, Cooper AA, Bibson RS. Postinfarction ventricular septal rupture: the importance of location of infarction and right ventricular function in determining survival. Circulation 1986;74:45-55 https://doi.org/10.1161/01.CIR.74.1.45
  5. Skillington PD, Davies RH, Luff AJ, et al. Surgical treatment for infarct-related ventricular septal defects. Improved early results combined with analysis of late functional status. J Thorac Cardiovasc Surg 1990;99:798-808
  6. Killen D, Reed W, Wathanacharoen S, McCallister B, Bell H. Postinfarctional rupture of the interventricular septum. J Cardiothorac Surg 1981;22:113-26
  7. Duncan AK, Jeffrey MP, Michael B, Michael EG, William AR. Early repair of postinfarction ventricular septal rupture. Ann Thorac Surg 1997;63:138-42 https://doi.org/10.1016/S0003-4975(96)00765-5
  8. David TE, Dale L, Sun Z. Postinfarction ventricular septal rupture: repair by endocardial patch with infarct exclusion. J Thorac Cardiovasc Surg 1995;110:1315-22 https://doi.org/10.1016/S0022-5223(95)70054-4
  9. Muehrcke D, Daggett WM Jr, Buckley MJ, Akins CW, Hilgenberg AD, Austen WG. Postinfarct ventricular septal defect repair: effect of coronary artery bypass grafting. Ann Thorac Surg 1992;54:876-83 https://doi.org/10.1016/0003-4975(92)90640-P
  10. Gold HK, Leinbach RC, Sanders CA, et al. Intra-aortic balloon pumping for ventricular septal defect or mitral regurgitation complicating acute myocardial infarction. Circulation 1973;47:1191
  11. Skillington PD, Davies RH, Luff AJ, et al. Surgical treatment for infarct-related ventricular septal defects. Improved early results combined with analysis of late functional status. J Thorac Cardiovasc Surg 1990;99:798-808