Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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A case of dapsone syndrome

Dapson 증후군 1례

  • Won, Yoo Jong (Department of Pediatrics, School of Medicine, Wonkwang University) ;
  • Kim, Ok Lan (Department of Pediatrics, School of Medicine, Wonkwang University) ;
  • Yu, Seung Taek (Department of Pediatrics, School of Medicine, Wonkwang University) ;
  • Yoon, Young Wook (Department of Pediatrics, School of Medicine, Wonkwang University) ;
  • Choi, Du Young (Department of Pediatrics, School of Medicine, Wonkwang University)
  • 원유종 (원광대학교 의과대학 소아과학교실) ;
  • 김옥란 (원광대학교 의과대학 소아과학교실) ;
  • 유승택 (원광대학교 의과대학 소아과학교실) ;
  • 윤영욱 (원광대학교 의과대학 소아과학교실) ;
  • 최두영 (원광대학교 의과대학 소아과학교실)
  • Received : 2007.02.05
  • Accepted : 2007.04.05
  • Published : 2007.05.15
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Abstract

Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the initial administration of the drug and results in unpredictable, sometimes fatal outcomes. This report deals with a 13-year-old girl's case with typical features of dapsone syndrome that included fever, exfoliative dermatitis, jaundice, hemolytic anemia and pleural effusion after being treated with dapsone for four weeks.

Dapsone은 나병과 여러 수포성 피부 질환의 치료에 널리 사용되고 있다. 일반적인 투여 용량의 dapsone은 부작용이 드물지만, 피부, 신경계, 위장관, 간, 신장과 혈액학적 합병증을 일으킬 수 있다. 이들 부작용 중 하나인 dapsone 증후군은 약물 투여 수주 후에 발생하여, 예측 불가능하게 진행하며 치명적인 경과를 취할 수 있는 중증 약물 과민 반응이다. 저자들은 dapsone 투여 4주 후에 열, 박탈성 피부염, 황달, 용혈성 빈혈, 늑막 삼출 등의 특징적인 임상 소견을 보인 dapsone 증후군 1례를 경험하였기에 보고하는 바이다.

Keywords

References

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