The Korean Journal of Pain

  • 제20권2호
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  • Pages.100-105
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  • 2007
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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백서를 이용한 수술 후 통증 유발 모형에서 척수강 내로 투여한 Ginsenosides의 효과

The Effect of Treatment with Intrathecal Ginsenosides in a Rat Model of Postoperative Pain

  • 신동진 (전남대학교 의과대학 마취통증의학교실) ;
  • 윤명하 (전남대학교 의과대학 마취통증의학교실) ;
  • 이형곤 (전남대학교 의과대학 마취통증의학교실) ;
  • 김웅모 (전남대학교 의과대학 마취통증의학교실) ;
  • 박병윤 (전남대학교 의과대학 마취통증의학교실) ;
  • 김여옥 (전남대학교 의과대학 마취통증의학교실) ;
  • 황란희 (두뇌한국21사업 전남대학교 의생명 인력사업단) ;
  • 최금화 (두뇌한국21사업 전남대학교 의생명 인력사업단)
  • Shin, Dong Jin (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Yoon, Myung Ha (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Lee, Hyung Gon (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Kim, Woong Mo (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Park, Byung Yun (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Kim, Yeo Ok (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Huang, Lan Ji (Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National University) ;
  • Cui, Jin Hua (Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National University)
  • 투고 : 2007.09.13
  • 심사 : 2007.11.05
  • 발행 : 2007.12.10
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초록

Background: Ginseng has been used to manage various types of pain in folk medicine. This study characterized the effect of treatment with intrathecal ginsenosides, the active components of ginseng in a postoperative pain model. Methods: Male Sprague-Dawley rats were implanted with lumbar intrathecal catheters. An incision was made in the plantar surface of the hindpaw. Withdrawal thresholds following the application of a von Frey filament to the wound site were measured. To determine the role of the opioid or GABA receptors following treatment with the ginsenosides, naloxone, bicuculline (a $GABA_A$ receptor antagonist), and saclofen (a $GABA_B$ receptor antagonist) were administered intrathecally 10 min before the delivery of the ginsenosides and the changes of the withdrawal thresholds after application of the von Frey filament were Observed. Results: Treatment with the intrathecal ginsenosides increased the withdrawal threshold in a dose dependent manner. Pre-treatment with intrathecal naloxone reversed the antinociceptive effect of the ginsenosides. However, pre-treatment with intrathecal bicuculline and saclofen failed to have an effect on the activity of the ginsenosides. Conclusions: These results suggest that ginsenosides are effective to alleviate the postoperative pain evoked by paw incision. The opioid receptor, but not GABA receptors, may be involved in the antinociceptive action of the ginsenosides at the spinal level.

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과제정보

연구 과제 주관 기관 : 한국학술진흥재단

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