The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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The Role of Opioid Receptor on the Analgesic Action of Intrathecal Sildenafil in Rats

백서의 척수강 내로 투여한 Sildenafil의 진통효과에 대한 Opioid 수용체 역할에 관한 연구

  • Lee, Hyung Gon (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam University) ;
  • Jeong, Chang Young (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam University) ;
  • Yoon, Myung Ha (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam University) ;
  • Kim, Woong Mo (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam University) ;
  • Shin, Seung Heon (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam University) ;
  • Kim, Yeo Ok (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam University) ;
  • Huang, Lan Ji (Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam University) ;
  • Cui, Jin Hua (Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam University)
  • 이형곤 (전남대학교 의과대학 마취통증의학교실) ;
  • 정창영 (전남대학교 의과대학 마취통증의학교실) ;
  • 윤명하 (전남대학교 의과대학 마취통증의학교실) ;
  • 김웅모 (전남대학교 의과대학 마취통증의학교실) ;
  • 신승헌 (전남대학교 의과대학 마취통증의학교실) ;
  • 김여옥 (전남대학교 의과대학 마취통증의학교실) ;
  • 황란희 (두뇌한국21사업 전남대학교 의생명 인력사업단) ;
  • 최금화 (두뇌한국21사업 전남대학교 의생명 인력사업단)
  • Received : 2007.03.27
  • Accepted : 2007.06.11
  • Published : 2007.06.30
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Abstract

Background: Intrathecal sildenafil has produced antinociception by increasing the cGMP through inhibition of phosphodiesterase 5. Spinal opioid receptor has been reported to be involved in the modulation of nociceptive transmission. The aim of this study was to examine the role of opioid receptor in the effect of sildenafil on the nociception evoked by formalin injection. Methods: Rats were implanted with lumbar intrathecal catheters. Formalin testing was used as a nociceptive model. Formalin-induced nociceptive behavior (flinching response) was observed. To clarify the role of the opioid receptor for the analgesic action of sildenafil, naloxone was administered intrathecally 10 min before sildenafil delivery, and formalin was then injected 10 min later. Results: Intrathecal sildenafil produced dose-dependent suppression of flinches in both phases during the formalin test. Intrathecal naloxone reversed the analgesic effect of sildenafil in both phases. Conclusions: Sildenafil is active against the nociceptive state that's evoked by a formalin stimulus, and the opioid receptor is involved in the analgesic action of sildenafil at thespinal level.

Keywords

Acknowledgement

Supported by : 전남대학교

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