Archives of Plastic Surgery

  • 제34권3호
  • /
  • Pages.298-304
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  • 2007
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
권호 표지

Poly-glycolic Acid(PGA)와 우태아 혈청(Fetal bovine serum, FBS)의 혼합물이 가토에서 골형성에 미치는 영향

The Effects of the Mixture of Fetal Bovine Serum and Poly-glycolic acid in Rabbit Calvarial Model

  • 성용덕 (영남대학교 의과대학 성형외과학교실) ;
  • 김용하 (영남대학교 의과대학 성형외과학교실) ;
  • 문영미 (영남대학교 의과대학 의료공학 연구소) ;
  • 김갑중 (안동대학교 자연대학 응용화학과) ;
  • 김연정 (안동대학교 자연대학 응용화학과) ;
  • 최식영 (안동대학교 자연대학 응용화학과)
  • Sung, Yong Duck (Department of Plastic & Reconstructive Surgery, College of Medicine, Yeungnam University) ;
  • Kim, Yong Ha (Department of Plastic & Reconstructive Surgery, College of Medicine, Yeungnam University) ;
  • Moon, Young Mi (Department of Tissue Engineering, College of Medicine, Yeungnam University) ;
  • Kim, Kap Joong (Applied Chemistry, Natural Science, Andong National University) ;
  • Kim, Yeon Jung (Applied Chemistry, Natural Science, Andong National University) ;
  • Choi, Sik Young (Applied Chemistry, Natural Science, Andong National University)
  • 투고 : 2006.08.28
  • 발행 : 2007.05.10
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초록

Purpose: This study was undertaken to investigate the osteogenic induction potential of PGA & FBS mixture on a calvarial defect in the rabbit. Methods: Twenty New zealand white rabbit, weighing from 3.5-4kg were allocated into each of the three groups. Four 8 mm sized bone defects were made on the parietal bone by drilling. In group I, the bony defects were implanted with $50{\mu}m$ thickness film containing mixture of PGA and FBS. In group II, with PGA only film, & in group III, the bony defects were left with no implants. Results were evaluated by using morphologic change, radiographic study, biochemical study and histologic examination at 1 week (group I n=7, group II n=7, group III n=14), 2 weeks (group I n=6, group II n=6, group III n=12) and 3 weeks (group I n=7, group II n=7, group III n=14) following implantation. Results: In the morphologic & radiographic study, the formation and corticalization of callus were observed earlier in group I than in groups II and III (p < 0.05). In histological examination, group I showed more abundant and faster new bone formation than in group II and III. In biochemical analysis, group I displayed more activity than in group II and III. Group I also showed more abundant osteopontin, osteocalcin than groups II and III. Conclusion: In conclusion, the results demonstrate that the mixture of PGA and FBS has an effect on osteoblastic formation in the rabbit model. It is considered that further evaluation of long term results on resorption, immunologic tissue reaction and response of applied mixture in the human model will be needed.

키워드

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