Archives of Plastic Surgery

  • 제34권3호
  • /
  • Pages.291-297
  • /
  • 2007
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
권호 표지

혈소판 농축액이 이식된 지방의 생존에 미치는 영향

The Effect of Platelet-Rich Plasma(PRP) on the Survival of the Autologous Fat Graft

  • 김승준 (고려대학교 의과대학 성형외과학교실) ;
  • 최원일 (고려대학교 의과대학 성형외과학교실) ;
  • 이병일 (고려대학교 의과대학 성형외과학교실) ;
  • 박승하 (고려대학교 의과대학 성형외과학교실) ;
  • 박철 (고려대학교 의과대학 성형외과학교실) ;
  • 구상환 (고려대학교 의과대학 성형외과학교실)
  • Kim, Seung Jun (Department of Plastic Surgery, Korea University College of Medicine) ;
  • Choi, Won Il (Department of Plastic Surgery, Korea University College of Medicine) ;
  • Lee, Byung Il (Department of Plastic Surgery, Korea University College of Medicine) ;
  • Park, Seung Ha (Department of Plastic Surgery, Korea University College of Medicine) ;
  • Park, Chul (Department of Plastic Surgery, Korea University College of Medicine) ;
  • Koo, Sang Hwan (Department of Plastic Surgery, Korea University College of Medicine)
  • 투고 : 2007.01.24
  • 발행 : 2007.05.10
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초록

Purpose: Platelet-rich plasma(PRP) contains protein growth factors, which are actively secreted by platelets to promote wound healing. However, it is not clear whether the injection of PRP into the autologous fat grafts increases the survival rate and the degree of angiogenesis. Methods: New Zealand White rabbit ears were injected fat with PRP, saline, insulin or isoproterenol (n=8/each group) for observation of the survival and degree of angiogenesis of the injected fat. The volume of the harvested fat and the degree of angiogenesis from dorsum of rabbit ears were evaluated 4, 8, and 12 weeks after the autologous fat graft. The degree of angiogenesis was measured with microvascular density (MVD) counts. Results: The volume of harvested fat decreased in a time-dependent manner after autologous fat grafts, but the decrease rate in volume of harvested fat was slower in PRP-injected group compared to that of other control groups. The difference in the volume of the harvested fat between PRP-injected group and other control groups became significant from 4 weeks after the autologous fat graft, and was maintained up to 12 weeks. However, there was no significant difference between PRP-injected group and insulin-injected group 8 and 12 weeks after the autologous fat graft. On the contrary, MVD counts increased in a time-dependent manner after autologous fat grafts. The MVD counts were significantly higher in PRP-and insulin-injected groups than in other control groups from 4 weeks after the autologous fat graft, and these differences were maintained up to 12 weeks. There was no correlation between mean platelet numbers and the volume of harvested fat. Conclusion: The present study demonstrates that PRP-injection into autologous fat grafts increases the survival rate and the degree of angiogenesis. Thus, PRP injection with autologous fat grafts would be a promising tool for maintaining the volume of the grafted fat.

키워드

과제정보

연구 과제 주관 기관 : 고려대학교

참고문헌

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