Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Topiramate can reduce the number of episodic attacks in cyclic vomiting syndrome : a case report

Topiramate 투여로 호전된 주기성 구토증 1례

  • Yum, Mi-Sun (Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Bae, Keun Wook (Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • You, Su Jeong (Department of Pediatrics, Epilepsy Center, College of Medicine, Inje University) ;
  • Ko, Tae Sung (Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan)
  • 염미선 (울산대학교 의과대학 소아과학교실) ;
  • 배근욱 (울산대학교 의과대학 소아과학교실) ;
  • 유수영 (인제대학교 의과대학 소아과학교실) ;
  • 고태성 (울산대학교 의과대학 소아과학교실)
  • Received : 2007.02.26
  • Accepted : 2007.03.15
  • Published : 2007.04.15
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Abstract

Cyclic vomiting syndrome (CVS) is a paroxysmal, recurrent vomiting disorder of unknown pathophysiology and target organ. It has been hypothesized that CVS shares the same mechanism as migraine. We describe here a 5-year-old boy with CVS characterized by episodic vomiting attacks. These recurrent vomiting episodes began at 3 years of age, occurred every month and lasted for 5 days at a time. At the time of admission, no abnormal physical or neurological findings were observed and laboratory findings, including brain MRI and endoscopic examination, revealed nothing specific. The vomiting episodes were self-limited but recurrent and severely interrupted his daily life. When this patient was treated with topiramate, he showed a marked increase of symptom-free periods.

주기성 구토증(cyclic vomiting syndrome, CVS)은 예측 불가능한 심한 구토가 특별한 원인 없이 시작되어 각 개인마다 일정한 임상 양상을 보이며 수 시간에서 수일간 지속되다가 저절로 호전되는 것을 반복하는 질환으로서, 그 임상 양상은 편두통과 많은 공통점을 보이며 그 병리생리학적 원인이 편두통과 유사한 것으로 추정되어지고 있다. 저자들은 만 3세 경부터 시작된 발작적이고 반복적인 주기적 구토를 주소로 내원한 5세 남아에서 주기적 구토증을 진단하였으며, 이 환아에서 대규모의 임상 연구를 통해 단독 요법으로 편두통의 예방에 효능이 있음이 인정된 광범위 항경련제인 topiramate(TPM)를 투여하여 그 증상이 호전됨을 경험하고 이를 보고하는 바이다.

Keywords

References

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