흰쥐의 감염된 전층피부결손에 미치는 은 함유 드레싱제재와 폴리우레탄 폼 드레싱제재의 비교관찰

Comparative Study of Acticoat® & Allevyn® on Infected Full-thickness Wound of the Rat Skin

  • 곡낙수 (중앙대학교 의과대학 성형외과학교실) ;
  • 김한구 (중앙대학교 의과대학 성형외과학교실) ;
  • 김승홍 (중앙대학교 의과대학 성형외과학교실) ;
  • 김우섭 (중앙대학교 의과대학 성형외과학교실) ;
  • 배태희 (중앙대학교 의과대학 성형외과학교실) ;
  • 김미경 (중앙대학교 의과대학 병리학교실)
  • Gok, Nak Soo (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Han Koo (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Seung Hong (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Woo Seob (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Bae, Tae Hee (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Mi Kyung (Department of Pathology, College of Medicine, Chung-Ang University)
  • 투고 : 2006.09.22
  • 발행 : 2007.03.10

초록

Purpose: $Allevyn^{(R)}$(Smith & Nephew, England) is a type of polyurethane foam material with good wound discharge absorption. $Acticoat^{(R)}$(Smith & Nephew, England) is a silver coated dressing material which is effective in infected wound. The purpose of this study is to compare the effects of dry gauze, $Acticoat^{(R)}$ and $Allevyn^{(R)}$ on infected full-thickness wound healing in rat. Methods: One hundred and twenty rats were divided into 3 groups: group I(dressing with dry gauze, n=40), group II(dressing with $Allevyn^{(R)}$, n=40), group III(dressing with $Acticoat^{(R)}$, n=40). A $15{\times}15mm$ square full-thickness wound was made on the dorsum and left open for 24 hours. The size of wound defects were measured each dressing changes. The histological evaluation was performed on the 3rd day, 7th day, 14th day, 21th day. Results: After the wound was left open for 24 hours, typical findings of bacterial infection was observed. After the 7th day, group III showed larger area of epithelialization, smaller defect size compared to those of two other groups. Complete replacement by fibrotic scar tissue was observed in group III with no signs of inflammation on the 14th day. By day 21, the average defect size in group III was decreased from initial 100% to 3.63%. while in group I and II, it was decreased to 62.66% and 53.62%, respectively. Conclusion: $Acticoat^{(R)}$ is an effective tool in the treatment of infected wound.

키워드

과제정보

연구 과제 주관 기관 : 중앙대학교

참고문헌

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