약학회지 (YAKHAK HOEJI)

  • 제51권5호
  • /
  • Pages.343-349
  • /
  • 2007
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  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

바위취 에탄올 추출물의 항산화 및 항노화 작용

Anti-oxidant and Anti-aging Activity on Saxifraga stolonifera MEERBURGH Ethanol Extract

  • 윤미연 (건국대학교 미생물공학과) ;
  • 임혜원 (이화여자대학교 생명과학과) ;
  • 심상수 (중앙대학교 약학대학) ;
  • 최태부 (건국대학교 미생물공학과)
  • Yoon, Mi-Yun (Dept. of Microbiological Engineering, Konkuk University) ;
  • Lim, Hye-Won (Dept. of Life Scienace, Ewha Womans University) ;
  • Sim, Sang-Soo (College of Pharmacy, Chung-Ang University) ;
  • Choe, Tae-Boo (Dept. of Microbiological Engineering, Konkuk University)
  • 발행 : 2007.10.31
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초록

To investigate the effect of ethanol extract of Saxifraga stolonifera MEERBURGH on skin care, we measured anti-oxidant and anti-aging activity. S. stolonifera ethanol extract itself had anti-oxidant activity in a dose-dependent manner in DPPH radical scavenging. Silica dose-dependently increased the intracellular ROS generation in RAW 264.7 cells. S. stolonifera ethanol extract inhibited silica-induced intracellular superoxide anion generation, $H_2O_2$ and hydroperoxide generation in RAW 264.7 cells. S. stolonifera ethanol extract significantly inhibited both hyaluronidase and elastase activity, also significantly inhibited MMP-1(collagenase) activity as well. In NIH 3T3 fibroblast cells, S. stolonifera ethanol extract significantly increased collagen-like polymer synthesis, which suggesting the S. stolonifera ethanol extract might be used as hydration and anti-wrinkle agents. From the above results, it is suggested that the main ingredients of S. stolonifera ethanol extract play an important role in anti-oxidant and anti-aging activity.

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