Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Immunological Roles of Pasteurella multocida Toxin (PMT) Using a PMT Mutant Strain

  • Kim, Tae-Jung (Biotheraphy Human Resources Center, Chonnam National University) ;
  • Toan, Nguyen Tat (College of Veterinary Medicine, Chonnam National University) ;
  • Jang, Eun-Jin (College of Veterinary Medicine, Chonnam National University) ;
  • Jung, Bock-Gie (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Jae-Il (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Bong-Joo (Biotheraphy Human Resources Center, Chonnam National University)
  • Published : 2007.08.30
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Abstract

The immunological role of the Pasteurella multocida toxin (PMT) in mice was examined using a PMT mutant strain. After a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. Moreover, PMT had no significant effect on the populations of CD4+, CD8+, CD3+, and CD19+ immunocytes in blood or on the populations of CD4+ and CD8+ splenocytes (P<0.01). However, there was a significant increase in the total number of cells in the BAL samples obtained from the wild-type P. multocida-inoculated mice. On the other hand, the level of IL-l expression decreased when the macrophages from the bronchio-alveolar lavage were stimulated with PMT. Overall, PMT appears to play some role (stimulating and/or inhibiting) in the immunological responses but further studies will be required to confirm this.

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References

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