Korean Journal of Poultry Science (한국가금학회지)

The Korean Society of Poultry Science (한국가금학회)
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Evolving Problem Analyses of Recent Marek's Disease

최근 진화하는 마렉병의 원인 분석

  • Jang, H.K. (Department of Infectious Diseases and Avian Diseases, College of Veterinary Medicine, Chonbuk National University) ;
  • Park, Y.M. (Department of Infectious Diseases and Avian Diseases, College of Veterinary Medicine, Chonbuk National University) ;
  • Cha, S.Y. (Department of Infectious Diseases and Avian Diseases, College of Veterinary Medicine, Chonbuk National University) ;
  • Park, J.B. (Department of Infectious Diseases and Avian Diseases, College of Veterinary Medicine, Chonbuk National University)
  • 장형관 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 박영명 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 차세연 (전북대학교 수의과대학 전염병학.조류질병학연구실) ;
  • 박종범 (전북대학교 수의과대학 전염병학.조류질병학연구실)
  • Published : 2007.12.31
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Abstract

Marek's disease (MD) is a highly contagious lymphoproliferative disease of poultry caused by the oncogenic herpesvirus designated Marek's disease virus (MDV). MD has a worldwide distribution and is thought to cause an annual loss over US$ one billion to the poultry industry. Originally described as a paralytic disease, today MD is mostly manifested as an acute disease with tumors in multiple visceral organs. MD is controlled essentially by the widespread use of live vaccines administered either in ovo into 18-day-old embryos or into chicks immediately after they hatch. In spite of the success of the vaccines in reducing the losses from the disease in the last 30 years, MDV strains have shown continuous evolution in virulence acquiring the ability to overcome the immune responses induced by the vaccines. During this period, different generations of MD vaccines have been introduced to protect birds from the increasingly virulent MDV strains. However, the virus will be countered each new vaccine strategy with ever more virulent strains. In spite of this concern, currently field problem from MD is likely to be controled by strategy of using bivalent vaccine. But, potential risk factors for outbreak of MD are still remained in this condition. The major factors can be thought that improper handling and incorrect administration of the vaccine, infection prior to establishment of immunity, suppression of immune system by environmental stress and outbreaks of more virulent MDV strain by using vaccine and genetic resistance of host.

Keywords

References

  1. Abbassi H, Coudert F, Cherel Y, Dambrine G, Brugere-Picoux J, Naciri M 1999 Renal Cryptosporidiosis (Cryptosporidium baileyi) in specific-pathogen-free chickens experimentally coinfected with Marek's disease virus. Avian Dis 43:738- 744 https://doi.org/10.2307/1592742
  2. Adair BM 2000 Immunopathogenesis of chicken anemia virus infection. Dev Comp Immunol 24:247-255 https://doi.org/10.1016/S0145-305X(99)00076-2
  3. Baaten BJ, Butter C, Davison TF 2004 Study of host-pathogen interactions to identify sustainable vaccine strategies to Marek's disease. Vet Immunol Immunopathol 100:165-177 https://doi.org/10.1016/j.vetimm.2004.04.009
  4. Bagust TJ, Grimes TM, Dennett DP 1979 Infection studies on a reticuloendotheliosis virus contaminant of a commercial Marek's disease vaccine. Aust Vet J 55:153-157 https://doi.org/10.1111/j.1751-0813.1979.tb15261.x
  5. Baigent SJ, Davison TF 2004. Marek's disease virus: biology and life cycle. Pages 62-77 In: Marek's disease, an evolving problem. Davison F and Nair V, (Ed.) Elsevier Academic Press, New York
  6. Baigent SJ, Petherbridge LJ, Smith LP, Zhao Y, Chesters PM, Nair VK. 2006a Herpesvirus of turkey reconstituted from bacterial artificial chromosome clones induces protection against Marek's disease. J Gen Virol 87:769-776 https://doi.org/10.1099/vir.0.81498-0
  7. Baigent SJ, Smith LP, Nair VK, Currie RJW 2006b Vaccinal control of Marek's disease: current challenges, and future strategies to maximize protection. Vet Immunol Immunopathol 112:78-86 https://doi.org/10.1016/j.vetimm.2006.03.014
  8. Barnes HJ 1996 Page 12 In: Avian hisopathology. Riddell C. (Ed) 2nd edn. American Association of Avian Pathologists, Pennsylvania
  9. Calnek BW 2001 Pathogenesis of Marek's disease virus infection. Pages 25-55 In: Marek's disease. Hirai K, (Ed.) Springer, Berlin, Germany
  10. Calnek BW, Adldinger HK, Kahn DE 1970 Feather follicle epithelium: A source of enveloped and infectious cell-free herpesvirus from Marek's disease. Avian Dis 14:219-233 https://doi.org/10.2307/1588466
  11. de Boer GF, Pol JM, Oei HL 1987 Biological characteristics of Marek's disease vaccine CVI-988 clone C1. Vet Q 1:16S- 28S
  12. Dudnikova E, Norkina S, Vlasov A, Slobodchuk A, Lee LF, Witter RL 2007 Evaluation of Marek's disease field isolates by the 'best fit' pathotyping assay. Avian Pathol 36:135-143 https://doi.org/10.1080/03079450701209857
  13. El-Lethey H, Huber-Eicher B, Jungi TW 2003 Exploration of stress-induced immunosuppression in chickens reveals both stress-resistant and stress-susceptible antigen responses. Vet Immunol Immunopathol 95:91-101 https://doi.org/10.1016/S0165-2427(02)00308-2
  14. Hu LB 1992 Role of humoral immunity and T cell subpopulations in the pathogenesis of chicken infectious anemia. M.Sc. Thesis, Cornell Univ., Ithaca, NY
  15. Hu LB, Lucio B, Schat KA 1993 Abrogation of age-related resistance to chicken infectious anemia by embryonal bursectomy. Avian Dis 37:157-169 https://doi.org/10.2307/1591469
  16. Jarosinski KW, Tischer BK, Trapp S, Osterrieder N 2006 Marek's disease virus: lytic replication, oncogenesis, and control. Expert Rev Vaccines 5:761-772 https://doi.org/10.1586/14760584.5.6.761
  17. Jeurissen SHM, Janse ME, Van Roozelaar DJ, Koch G, De Boer GF 1992 Susceptibility of thymocytes for infection by chicken anemia virus is related to pre and post-hatching developments. Dev Immunol 2:123-129 https://doi.org/10.1155/1992/52484
  18. Kreager KS 1998 Chicken industry strategies for control of tumor virus infections. Poult Sci 1998 77:1213-1216 https://doi.org/10.1093/ps/77.8.1213
  19. Landman WJ, vd Bogaard AE, Doornenbal P, Tooten PC, Elbers AR, Gruys E 1998 The role of various agents in chicken amyloid arthropathy. Amyloid 5:266-278 https://doi.org/10.3109/13506129809007300
  20. Marek J 1907 Multiple Nervenentzundung (polyneuritis) bei Huhnern. Deutsche Tierarztliche Wochenschrift 15:417-421
  21. McConnell CDG, Adair BM, McNulty MS 1993a Effects of chicken anemia virus on macrophage function in chickens. Avian Dis 37:358-365 https://doi.org/10.2307/1591659
  22. McConnell CDG, Adair BM, McNulty MS 1993b Effects of chicken anemia virus on cell-mediated immune function in chickens exposed to the virus by natural route. Avian Dis 37:366-374 https://doi.org/10.2307/1591660
  23. McKay JC 1998 A poultry breeder's approach to avian neoplasia. Avian Pathol 27:S74-S77 https://doi.org/10.1080/03079459808419277
  24. Morimura T, Ohashi K, Sugimoto C, Onuma M 1998 Pathogenesis of Marek's disease (MD) and possible mechanisms of immunity induced by MD vaccine. J Vet Med Sci 60:1-8 https://doi.org/10.1292/jvms.60.1
  25. Morrow C and Fehler F 2004 Marek's disease: A worldwide problem Pages 49-61 In: Marek's disease, an evolving problem. Davison F and Nair V, (Ed.) Elsevier Academic Press, New York
  26. Nair V 2005 Evolution of Marek's disease: a paradigm for incessant race between the pathogen and the host. Vet J. 170:175-183 https://doi.org/10.1016/j.tvjl.2004.05.009
  27. Nazerian K, Lee LF, Yanagida N, Ogawa R 1992 Protection against Marek's disease by a fowlpox virus recombinant expressing the glycoprotein B of Marek's disease virus. J Virol 66:1409-1413
  28. Otaki Y, Saito K, Tajima M, Nomura Y 1992 Persistence of maternal antibody to chicken anaemia agent and its effects on the susceptibility of young chickens. Avian Pathol 21:147- 151 https://doi.org/10.1080/03079459208418828
  29. Pennycott TW, Duncan G, Venugopal K 2003 Marek's disease, candidiasis and megabacteriosis in a flock of chickens (Gallus gallus domesticus) and Japanese quail (Coturnix japonica). Vet Rec 153:293-297 https://doi.org/10.1136/vr.153.10.293
  30. Petherbridge L, Brown AC, Baigent SJ, Howes K, Sacco MA, Osterrieder N, Nair VK 2004 Oncogenicity of virulent Marek's disease virus cloned as bacterial artificial chromosomes. J Virol 78:13376-13380 https://doi.org/10.1128/JVI.78.23.13376-13380.2004
  31. Petherbridge L, Howes K, Baigent SJ, Sacco MA, Evans S, Osterrieder N, Nair V 2003 Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccines. J Virol 77:8712-8718 https://doi.org/10.1128/JVI.77.16.8712-8718.2003
  32. Powell PC, Rennie M 1978 Marek's disease tumour-specific antigen induced by the herpesvirus of turkeys in vaccinated chickens. Vet Rec 103:232-233 https://doi.org/10.1136/vr.103.11.232
  33. Rispens BH, van Vloten H, Mastenbroek N, Maas HJ, Schat KA 1972 Control of Marek's disease in the Netherlands. I. Isolation of an avirulent Marek's disease virus (strain CVI 988) and its use in laboratory vaccination trials. Avian Dis. 16:108-125 https://doi.org/10.2307/1588905
  34. Schumacher D, Tischer BK, Fuchs W, Osterrieder N 2000 Reconstitution of Marek's disease virus serotype 1 (MDV-1) from DNA cloned as a bacterial artificial chromosome and characterization of a glycoprotein B-negative MDV-1 mutant. J Virol 74:11088-11098 https://doi.org/10.1128/JVI.74.23.11088-11098.2000
  35. Schumacher D, Tischer BK, Teifke JP, Wink K, Osterrieder N 2002 Generation of a permanent cell line that supports efficient growth of Marek's disease virus (MDV) by constitutive expression of MDV glycoprotein E. J Gen Virol 83:1987- 1992 https://doi.org/10.1099/0022-1317-83-8-1987
  36. Spatz SJ, Petherbridge L, Zhao Y, Nair V. 2007a Comparvtive full-length sequence analysis of oncogenic and vaccine (Rispens) strains of Marek's disease virus. J Gen Virol 88:1080- 1096 https://doi.org/10.1099/vir.0.82600-0
  37. Spatz SJ, Zhao Y, Petherbridge L, Smith LP, Baigent SJ, Nair V. 2007b Comparative sequence of a highly oncogenic but horizontal spread-defective clone of Marek's disease virus. Virus Genes 35:753-766 https://doi.org/10.1007/s11262-007-0157-1
  38. Takagi M, Ishikawa K, Nagai H, Sasaki T, Gotoh K, Koyama H 1996 Detection of contamination of vaccines with the reticuloendotheliosis virus by reverse transcriptase polymerase chain reaction (RT-PCR). Virus Res 40:113-121 https://doi.org/10.1016/0168-1702(95)01259-1
  39. Tsukamoto K, Kojima C, Komori Y, Tanimura N, Mase M, Yamaguchi S 1999 Protection of chickens against very virulent infectious bursal disease virus (IBDV) and Marek's disease virus (MDV) with a recombinant MDV expressing IBDV VP2. Virology 257:352-362 https://doi.org/10.1006/viro.1999.9641
  40. Witter RL 1997 Increased virulence of Marek's disease virus field isolates. Avian Dis 41:149-163 https://doi.org/10.2307/1592455
  41. Witter RL 1998 The changing landscape of Marek's disease. Avian Pathol 27:S46-S53 https://doi.org/10.1080/03079459808419292
  42. Witter RL 2001 Protective efficacy of Marek's disease vaccines. Pages 57-90 In: Marek's disease. Hirai K, (Ed.) Springer, Berlin, Germany
  43. Witter RL 2005a Marek's disease: the continuing struggle between pathogen and host. Vet J 170:149-150 https://doi.org/10.1016/j.tvjl.2004.10.005
  44. Witter RL, Calnek BW, Buscaglia C, Gimeno IM, Schat KA 2005b Classification of Marek's disease viruses according to pathotype: philosophy and methodology. Avian Pathol 34: 75-90 https://doi.org/10.1080/03079450500059255
  45. Witter RL, Schat KA 2003 Marek's disease Pages 407-465 In: Disease of Poultry. Saif YM, (Ed.) 11th edn, Iowa State Press, Iowa
  46. Witter RL, Sharma JM, Lee LF, Opitz HM, Henry CW 1984 Field trials to test the efficacy of polyvalent Marek's disease vaccines in broilers. Avian Dis 28:44-60 https://doi.org/10.2307/1590127
  47. Yuasa N, Noguchi T, Furuta K, Yoshida I 1980 Maternal antibody and its effects on the susceptibility to chicken anemia agent. Avian Dis 24:197-201 https://doi.org/10.2307/1589779