Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Suppressive Effects of Korean Indigenous Acanthopanax divaritacus on the Allergic Inflammation

  • Park, Seul-Ki (Department of Medical Biotechnology, SoonChunHyang University) ;
  • Kim, Jum-Ji (Department of Medical Biotechnology, SoonChunHyang University) ;
  • Jeon, Yu-Mi (Department of Medical Biotechnology, SoonChunHyang University) ;
  • Lee, Mi-Young (Department of Medical Biotechnology, SoonChunHyang University)
  • Published : 2007.09.30
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Abstract

The water extracts of root, stem, and leaf from Korean indigenous Acanthopanax divaritacus were examined for their suppressive effects against allergic inflammations such as lipoxygenase activity, ${\beta}-hexosaminidase$ release, inflammatory cytokine production, and serum IgE level. The root extract inhibited the release of ${\beta}-hexosaminidase$, a degranulation marker, from rat basophilic leukemia cells (RBL-2H3) much more potently than the stem and leaf extracts. The root extract also significantly reduced the expression of $TNF-{\alpha}\;and\;IL-1{\beta}$ in the RBL-2H3 cells challenged with antigen. Moreover, there was a significant fall in the serum IgE level by the treatment of the root extract. Taken together, the root extract could be the most potent inhibitor of allergic inflammation, suppressing ${\beta}-hexosaminidase$ release and inflammatory cytokine expression, as well as reducing the rise of serum IgE level.

Keywords

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